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Next-Generation Mouse Models: Tau Knock-ins and Human Chimeras

CONFERENCE COVERAGE 2016-12-08 Add Private note Add An editorial note Conference Coverage Scientists seeking better mouse models for Alzheimer’s disease recently developed human mutant APP knock-ins (see related SfN story). The slowly developing pathology in these mice may better ...

Knock-In Alzheimer’s Mice Catch on More Broadly in the Field

CONFERENCE COVERAGE 2016-12-08 Add Private note Add An editorial note Conference Coverage Scientists agree that mouse models of Alzheimer’s only partially recapitulate the disease and, more ominously, that their strong overexpression of human AD genes renders them prone to artifacts. ...

Society for Neuroscience

CONFERENCE COVERAGE SERIES Add Private note Add An editorial note Astrocytes and Exosomes Implicated in Protein Propagation Knock-In Alzheimer’s Mice Catch on More Broadly in the Field Next-Generation Mouse Models: Tau Knock-ins and Human Chimeras When more than 30,000 registrants ...

New Reporter Cells Parse Differences Between Tau Strains

RESEARCH NEWS 2016-12-08 Add Private note Add An editorial note Research News Misfolded tau forms fibrillar “seeds” that lure properly folded tau monomers into their toxic fold. Now, using new cell lines designed to detect such molecular subterfuge, researchers led by Nobel ...

Astrocytes and Exosomes Implicated in Protein Propagation

CONFERENCE COVERAGE 2016-12-07 Add Private note Add An editorial note Conference Coverage Many researchers now believe that misfolded proteins spread from cell to cell across the brain, corrupting normal proteins as they go, yet exactly how this propagation would happen remains unclear ...

Is Alzheimer’s Disease a Uniquely Human Disorder?

WEBINAR 2016-12-07 Add Private note Add An editorial note Humans are not alone in accumulating Aβ in their brain. Squirrel monkeys, vervets, lemurs, apes, other nonhuman primates, and even dogs develop copious amyloid plaques and cerebral amyloid angiopathy as they age. ...

PXT864

THERAPEUTICS Add Private note Add An editorial note Pharnext PXT00864 Small Molecule Other Neurotransmitters From February 2013 to June 2015, Pharnext ran PLEODIAL I, a Phase 2 study in Bordeaux and several other sites in France. It compared an eight-week course (four ...

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