Huntington’s Strategies Tap Transcription, Htt Phosphorylation

RESEARCH NEWS 2012-02-20 Research News Two potential approaches for tackling Huntington’s disease come to the fore in this week’s literature—an intriguing mechanism begging for a drug, and a promising compound with an unknown mechanism. In the February 17 Cell, researchers led by

Are Broken Genes Common in Humans?

RESEARCH NEWS 2012-02-20 Research News Previous genome studies suggest that all of us possess a few hundred non-functional genes. Is this number accurate, and if so, what does it mean for human health? In the February 17 Science, a large international group led by Daniel MacArthu

Mariana Urse

Romania

PAPER Haacke EM, Beggs CB, Habib C

The role of venous abnormalities in neurological disease.

Rev Recent Clin Trials. 2012 May;7(2):100-16. PubMed: 22338620

PAPER Gass J, Prudencio M, Stetler C, Petrucelli L

Progranulin: An emerging target for FTLD therapies.

Brain Res. 2012 Jan 28; PubMed: 22338605

PAPER Flight MH

Neurodegenerative disease: Harnessing virus-mediated mitochondrial protection to combat neurodegeneration.

Nat Rev Drug Discov. 2012 Mar;11(3):188-9. PubMed: 22338641

PAPER d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor.

J Neuroinflammation. 2012;9:31. PubMed: 22335939

PAPER Higley MJ, Sabatini BL

Calcium signaling in dendritic spines.

Cold Spring Harb Perspect Biol. 2012 Apr;4(4):a005686. PubMed: 22338091

PAPER Haines DS, Lee JE, Beauparlant SL, Kyle DB, den Besten W, Sweredoski MJ, Graham RL, Hess S, Deshaies RJ

Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

Mol Cell Proteomics. 2012 Feb 14; PubMed: 22337587

PAPER Fujimoto M, Hayashi T, Urfer R, Mita S, Su TP

Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor.

Synapse. 2012 Jul;66(7):630-9. PubMed: 22337473

PAPER Merrill DA, Siddarth P, Saito NY, Ercoli LM, Burggren AC, Kepe V, Lavretsky H, Miller KJ, Kim J, Huang SC, Bookheimer SY, Barrio JR, Small GW

Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia.

Int Psychogeriatr. 2012 Jul;24(7):1076-84. PubMed: 22335970

PAPER Bidzan L, Grabowski J, Dutczak B, Bidzan M

[Sleep disorders in the preclinical period of the Alzheimer's disease].

Psychiatr Pol. 2011 Nov-Dec;45(6):851-60. PubMed: 22335128

PAPER Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY

Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity.

J Pineal Res. 2012 Jan 30; PubMed: 22335252

PAPER Lui VW, Lam LC, Chau RC, Fung AW, Wong BM, Leung GT, Leung KF, Chiu HF, Karlawish JH, Appelbaum PS

Capacity to make decisions on medication management in Chinese older persons with mild cognitive impairment and mild Alzheimer's disease.

Int Psychogeriatr. 2012 Jul;24(7):1103-11. PubMed: 22336031

PAPER Croisile B, Tedesco A, Gavant S, Minssieux-Catrix G, Mollion H

[The specialist-referred patients represents 42% of the activity of an Academic Memory Clinic.]

Presse Med. 2012 Feb 13; PubMed: 22336483