COMMENT I would like to thank all contributors to the discussion for sharing really interesting thoughts. I also strongly appreciate the participation of industry and their constructive input. This type of interaction is very helpful and shows how far the field ...
COMMENT Bart de Strooper conducted a comprehensive analysis of clinical studies of Semagacestat based on published data and made a convincing argument that the failed clinical trial does not disqualify γ-secretase as a target for AD drug development. We should ...
PAPER Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M, Hui CC, Clevers H, Dotto GP, Radtke F12590261
PAPER Mellman I, Coukos G, Dranoff G22193102
COMMENT Arguing about whether it is Aβ40, Aβ42 or not is missing the important point: It is aggregated in an amyloid-like fashion, because it reacts with a large number of antibodies that only react with aggregated or fibrillar conformations. If it is aggregated ...
RESEARCH NEWS 2015-03-06 Research News As the field inches toward treating Alzheimer’s disease at the preclinical stage, researchers need to find sensitive tests that can tell if therapies work. Measures that pick up subtle cognitive decline in healthy elderly are coming along, ...
COMMENT If Winton et al. had reported on accumulation of APP in the triple transgenic there would not have been such a reaction. But the paper and the Alzforum webinar questioned the whole area of intraneuronal Aβ. Many in the field thought this was going too far ...
COMMENT The major point made by Winton et al. was that many of the antibodies raised against Aβ also crossreact with APP and other APP fragments, not that intracellular Aβ does not exist in the transgenic mice at all. Besides, Aβ deposition, which precedes ...
PAPER Nishteswar K, Joshi H, Karra RD25737604
PAPER Maeda Y, Kaneda E, Hasegawa S, Yoshida S, Fujii M, Sasaki H25735429
PAPER Chen Y, Wang A, Tang J, Wei D, Li P, Chen K, Wang Y, Zhang Z
Association of White Matter Integrity and Cognitive Functions in Patients With Subcortical Silent Lacunar Infarcts.Stroke. 2015 Mar 3; PubMed: 25737316
PAPER Narayan SM, Varghese M, Hepburn K, Lewis M, Paul I, Bhimani R25735742
PAPER Heinzelman P, Priebe MC
Engineering superactive granulocyte macrophage colony-stimulating factor transferrin fusion proteins as orally-delivered candidate agents for treating neurodegenerative disease.Biotechnol Prog. 2015 Mar 3; PubMed: 25737095
PAPER Ruxton K, Woodman RJ, Mangoni AA
Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: a systematic review and meta-analysis.Br J Clin Pharmacol. 2015 Mar 2; PubMed: 25735839
PAPER Hamada Y, Miyamoto N, Kiso Y25736996
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