Patti Becker

ADULT CARE LOCATORS of Tucson
TUCSON, United States

Julia George on α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.

COMMENT What I find most compelling about this work is the purification of helical α-synuclein from a cellular source. It is a long-standing hypothesis, based on conserved protein domains, that the active form of synuclein should be helical, but it has been diffi

Julia George

University of Illinois at Urbana/Champaign
Urbana, United States

Joseph Mazzulli on α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.

COMMENT These are interesting observations presented by Bartels et al. The data suggest that equilibrium may exist between a tetrameric aggregation-incompetent α-synuclein species, and an aggregation-competent monomer. Shifting the equilibrium to the monomeric fo

Harry Ischiropoulos

University of Pennsylvania Medical School
Philadelphia, United States

PAPER Ryan J, Carrière I, Scali J, Dartigues JF, Tzourio C, Poncet M, Ritchie K, Ancelin ML

Characteristics of hormone therapy, cognitive function, and dementia: the prospective 3C Study.

Neurology. 2009 Nov 24;73(21):1729-37. PubMed: 19933973

Christian Reid

United States

PAPER Roy-Desruisseaux J, Landry J, Bocti C, Tessier D, Hottin P, Trudel JF

Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia.

Ann Pharmacother. 2011 Sep;45(9):e51. PubMed: 21852591

PAPER Sae-Ung K, Uéda K, Govitrapong P, Phansuwan-Pujito P

Melatonin reduces the expression of alpha-synuclein in the dopamine containing neuronal regions of amphetamine-treated postnatal rats.

J Pineal Res. 2012 Jan;52(1):128-37. PubMed: 21851386

PAPER Sargeant TJ, Wang S, Bradley J, Smith NJ, Raha AA, McNair R, Ziegler RJ, Cheng SH, Cox TM, Cachón-González MB

Adeno-associated virus-mediated expression of β-hexosaminidase prevents neuronal loss in the Sandhoff mouse brain.

Hum Mol Genet. 2011 Nov 15;20(22):4371-80. Epub 2011 Aug 18 PubMed: 21852247

PAPER Bowden JB, Abraham WC, Harris KM

Differential effects of strain, circadian cycle, and stimulation pattern on LTP and concurrent LTD in the dentate gyrus of freely moving rats.

Hippocampus. 2011 Aug 18; PubMed: 21853503

PAPER Lee SG, Kim K, Kegelman TP, Dash R, Das SK, Choi JK, Emdad L, Howlett EL, Jeon HY, Su ZZ, Yoo BK, Sarkar D, Kim SH, Kang DC, Fisher PB

Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity.

Cancer Res. 2011 Oct 15;71(20):6514-23. PubMed: 21852380

PAPER Ren H, Fu K, Wang D, Mu C, Wang G

Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL.

J Biol Chem. 2011 Oct 7;286(40):35308-17. PubMed: 21852238

PAPER Hu Y, Tang B, Guo J, Wu X, Sun Q, Shi C, Hu L, Wang C, Wang L, Tan L, Shen L, Yan X, Zhang H

Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.

J Neurol. 2011 Aug 19; PubMed: 21853288

PAPER Boeve BF

The multiple phenotypes of corticobasal syndrome and corticobasal degeneration: implications for further study.

J Mol Neurosci. 2011 Nov;45(3):350-3. PubMed: 21853287