COMMENT Chronic hippocampal seizures impair cognition, an all-too-common biological comorbidity of temporal lobe epilepsy. What can be done? In the face of irreversible hippocampal cell loss followed by extensive structural rearrangements due to axonal sprouting, ...
RESEARCH NEWS 2017-10-20 Research News In Alzheimer’s disease, seizures in the hippocampus contribute to cognitive decline. Scientists have known for some time that this correlates with persistent loss of the calcium-binding protein calbindin-D28k, a regulator of synaptic ...
PAPER Karádi K, Janszky J, Gyimesi C, Horváth Z, Lucza T, Dóczi T, Kállai J, Abrahám H
Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy.Epilepsy Behav. 2012 Sep;25(1):110-9. Epub 2012 Jul 15 PubMed: 22796338
PAPER Nahm WK, Noebels JL
Nonobligate role of early or sustained expression of immediate-early gene proteins c-fos, c-jun, and Zif/268 in hippocampal mossy fiber sprouting.J Neurosci. 1998 Nov 15;18(22):9245-55. PubMed: 9801364
RESEARCH NEWS 2017-10-20 Research News ALS used to be thought of as a disease purely of the motor system, but more recently scientists have uncovered ties with frontotemporal dementia, and even certain neuropsychiatric diseases. Now, scientists led by Orla Hardiman, Beaumont ...
PAPER Lopez-Meraz ML, Wasterlain CG, Rocha LL, Allen S, Niquet J
Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.Neurobiol Dis. 2010 Feb;37(2):394-402. Epub 2009 Oct 29 PubMed: 19879360
PAPER Nägerl UV, Mody I, Jeub M, Lie AA, Elger CE, Beck H
Surviving granule cells of the sclerotic human hippocampus have reduced Ca(2+) influx because of a loss of calbindin-D(28k) in temporal lobe epilepsy.J Neurosci. 2000 Mar 1;20(5):1831-6. PubMed: 10684884
PAPER Chuquilin M, Wymer S, Wymer J
Increasing Evidence for an Association Between Amyotrophic Lateral Sclerosis and Psychiatric Disorders.JAMA Neurol. 2017 Oct 16; PubMed: 29049449
PAPER O'Brien M, Burke T, Heverin M, Vajda A, McLaughlin R, Gibbons J, Byrne S, Pinto-Grau M, Elamin M, Pender N, Hardiman O
Clustering of Neuropsychiatric Disease in First-Degree and Second-Degree Relatives of Patients With Amyotrophic Lateral Sclerosis.JAMA Neurol. 2017 Oct 16; PubMed: 29049464
PAPER Li M, Deng W, He Z, Wang Q, Huang C, Jiang L, Gong Q, Ziedonis DM, King JA, Ma X, Zhang N, Li T25819347
Emory University School of MedicineAtlanta, United States
COMMENT Rosshart et al. have made a great contribution to our understanding of the role of gut microbiome in determining disease phenotypes in mouse models. This work highlights the importance of reporting experimental details, and raises an issue that the field ...
Malu G. Tansey, Madelyn Houser, Andrew Neish on Microbiota from Wild Mice Protect Lab Mice from Disease
COMMENT Our understanding of complex disorders has been immeasurably advanced with the use of model organisms such as mice. The use of inbred strains maintained under highly controlled conditions necessarily limits potential variables that typically confound in ...
RESEARCH NEWS 2017-10-20 Research News In the confines of the animal room, lab mice reared for research encounter few microbes. While this safeguards against random infections and improves experimental reproducibility, the artificially sterile environment on its own may have ...
PAPER Reese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly RP, Jameson SC, Masopust D, Haining WN, Virgin HW
Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.Cell Host Microbe. 2016 May 11;19(5):713-9. Epub 2016 Apr 20 PubMed: 27107939
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