PAPER Cho HJ, Liu G, Jin SM, Parisiadou L, Xie C, Yu J, Sun L, Ma B, Ding J, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans JM, He P, Troncoso JC, Shen Y, Cai H
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PAPER Ramsden N, Perrin J, Ren Z, Lee BD, Zinn N, Dawson VL, Tam D, Bova M, Lang M, Drewes G, Bantscheff M, Bard F, Dawson TM, Hopf C
Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons.
ACS Chem Biol. 2011 Oct 21;6(10):1021-8. PubMed: 21812418PAPER Biosa A, Trancikova A, Civiero L, Glauser L, Bubacco L, Greggio E, Moore DJ
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
Hum Mol Genet. 2013 Mar 15;22(6):1140-56. PubMed: 23241358PAPER Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
J Neural Transm (Vienna). 2011 May;118(5):795-808. Epub 2011 May 7 PubMed: 21552986M. Flint Beal on Protein Destroying Muscle, Bone, Nerves Parks on Mitochondria
COMMENT The link between these two papers is that VCP mutations have deleterious effects on mitochondria. However, the two groups approach this from different directions. Plun-Favreau et al. studied mitochondrial function in fibroblasts and show that there is unc
PAPER Pomerantz BJ, Reznikov LL, Harken AH, Dinarello CA
Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta.
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2871-6. PubMed: 11226333PAPER Gangemi S, Basile G, Merendino RA, Minciullo PL, Novick D, Rubinstein M, Dinarello CA, Lo Balbo C, Franceschi C, Basili S, D' Urbano E, DavĂ G, Nicita-Mauro V, Romano M
Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
Exp Gerontol. 2003 Jun;38(6):669-72. PubMed: 12814802Gunnar Gouras on Like Star Born of Supernova, Plaque Born of Exploded Neuron?
COMMENT I'd like to clarify and extend my quoted comments about the interesting talk by Charlie Glabe at the AD/PD meeting. I was mainly referring to his new images of nuclear aggregates. Charlie did also show very nice new images of plaques appearing to ari
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