206901 RESULTS

A Change in Sleep Habits from Normal to Long: Harbinger of Dementia?

RESEARCH NEWS 2017-02-25 Research News Wake up, sleepyhead—your risk of dementia may have just doubled. According to a study published February 22 in Neurology, people who slumber for more than nine hours per night have twice the risk of dementia as people who sleep for just six ...

Marco Colonna on Does Soluble TREM2 Rile Up Microglia?

COMMENT The article represents a potentially interesting finding regarding the role of sTREM2 in triggering microglial activation. Although it is known that there is an increase in sTREM2 in many disease states, the role that sTREM2 plays is still relatively ...

Chimeric AD Model Shows Human Neurons Are Uniquely Vulnerable to Aβ

RESEARCH NEWS 2017-02-25 Research News Mouse models of Alzheimer’s disease develop massive amyloidosis without losing many neurons, making them incomplete models of AD. In the February 23 Neuron, researchers led by Bart De Strooper and Pierre Vanderhaeghen at KU Leuven, Belgium, ...

Gary Landreth on Does Soluble TREM2 Rile Up Microglia?

COMMENT Zhong et al. report that soluble forms of TREM2 are able to elicit a robust proinflammatory response and promote survival in primary microglia. These findings provide a completely novel take on the biological roles of soluble TREM2. Previous work has ...

Marco Colonna

Washington University School of Medicine
Saint Louis, United States

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