AβPP

ANTIBODY polyclonal manufacturer Cat# LS-C88784<br />manufacturer: LifeSpan Biosciences immunogen = synthetic peptide from aa 8-17 of human amyloid beta-protein liquid, PBS, BSA, azide, affinity purified APP IgG APP, APLP, AICD Autogen Bioclear Rabbit Human

Kenneth Van Blarcom

South Natick, United States

Freya Vercauteren

McGill University
Montreal, Canada

Rudolf Bloechl on Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5.

COMMENT The very interesting report by Renner et al. demonstrates Aβ-induced clustering of mGluR5 receptors and suggests that membrane-bound Aβ oligomers interact with mGluR5. Since chemical crosslinking of the receptor and application of Aβ oligomers produce sim

PAPER Popkirov SG, Manahan-Vaughan D

Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses.

Cereb Cortex. 2011 Mar;21(3):501-9. PubMed: 20525770

PAPER Traynor BJ, Nalls M, Lai SL, Gibbs RJ, Schymick JC, Arepalli S, Hernandez D, van der Brug MP, Johnson JO, Dillman A, Cookson M, Moglia C, Calvo A, Restagno G, Mora G, Chiò A

Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12335-8. PubMed: 20566859

PAPER Fukuda T, Yamagata K, Fujiyama S, Matsumoto T, Koshida I, Yoshimura K, Mihara M, Naitou M, Endoh H, Nakamura T, Akimoto C, Yamamoto Y, Katagiri T, Foulds C, Takezawa S, Kitagawa H, Takeyama K, O'Malley BW, Kato S

DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs.

Nat Cell Biol. 2007 May;9(5):604-11. PubMed: 17435748

PAPER Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R

The Microprocessor complex mediates the genesis of microRNAs.

Nature. 2004 Nov 11;432(7014):235-40. PubMed: 15531877

PAPER Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G

Numerous microRNPs in neuronal cells containing novel microRNAs.

RNA. 2003 Feb;9(2):180-6. PubMed: 12554860

Michael Wolfe on Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

COMMENT This is a solid study that provides important confirmation that presenilin is a zymogen that cuts itself (i.e., it is its own “presenilinase”) and that autoproteolysis occurs stepwise, every ~3 amino acids, similar to what is seen with γ-secretase substra

Paul Coleman on Law and Disorder—APPswe Patent Suits Raise Ruckus Again

COMMENT I read this news story with sadness. I regret the lack of investigators cooperating on the basis of mutual trust and a handshake. Of course, that is still possible among some, but these days commercial/monetary/legal issues are too often inserted to the d

Motor Neuron Disease Risk Factors: Fresh miRNA Clue, KIFAP3 Letdown

RESEARCH NEWS 2010-06-29 Research News Sifting through the genome has netted several mutations responsible for motor neuron diseases, but scientists still cannot explain the cause for most incidences. For amyotrophic lateral sclerosis (ALS), an adult-onset condition, genetics exp

AβPP

ANTIBODY polyclonal manufacturer Cat# LS-B3672<br /> manufacturer: LifeSpan Biosciences immunogen = peptide corresp. to aa737-751 of human amyloid A4 protein precursor (APP) or residues 85-99 of the C99 fragment generated by β- and γ-secretases. liquid, PBS,

AβPP

ANTIBODY polyclonal manufacturer Cat# LS-B3671<br /> manufacturer: LifeSpan Biosciences immunogen = peptide corresp. to aa653-662 of human amyloid A4 protein precursor (APP) or aa1-10 of the 4K Ab peptide generated by β- and γ-secretases. liquid, PBS, azide,

AβPP (J4H9)

ANTIBODY monoclonal J4H9 manufacturer Cat# LS-B2970<br /> manufacturer: LifeSpan Biosciences immunogen = APP antibody was raised against recombinant human APP (18-289aa) purified from E. coli liquid, PBS, azide APP IgG_2b, κ APP, APLP,