PAPER Henderson IC, Berry DA, Demetri GD, Cirrincione CT, Goldstein LJ, Martino S, Ingle JN, Cooper MR, Hayes DF, Tkaczuk KH, Fleming G, Holland JF, Duggan DB, Carpenter JT, Frei E, Schilsky RL, Wood WC, Muss HB, Norton L

Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer.

J Clin Oncol. 2003 Mar 15;21(6):976-83. PubMed: 12637460

Elias Akoury

Germany

Second Study Sees Intron in FTLD Gene Translated

RESEARCH NEWS 2013-02-15 Research News Just days after the first report of a highly eccentric translation mechanism in the major genetic forms of ALS and FTLD comes a second paper showing the same phenomenon. In the February 12 Neuron, researchers led by Leonard Petrucelli at the

Does Estrogen Put the Brakes on Aging in ApoE4-Positive Cells?

RESEARCH NEWS 2013-02-15 Research News White blood cells age quickly in post-menopausal women who carry the ApoE4 gene, but estrogen slows that decline, scientists report February 13 in PLoS ONE. Natalie Rasgon at Stanford University School of Medicine, California, and colleagues

Combination Trials: FDA Puts Flesh on Bones of Draft Guidance

CONFERENCE COVERAGE 2013-02-15 Conference Coverage When the U.S. Food and Drug Administration in 2010 issued a draft guidance on developing drug combinations, it was written primarily with anti-infectives and cancer drugs in mind. Alzheimer's disease clinicians who have read the g

Brain Electrodes Help Early PD, But Still Risky and Costly

RESEARCH NEWS 2013-02-15 Research News Electrodes inserted into specific brain areas can help some people with advanced Parkinson’s disease (PD) who no longer respond well to medication. Now, research in the February 14 New England Journal of Medicine suggests that the therapy, k

PAPER Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

Acta Neuropathol. 2013 May;125(5):753-69. PubMed: 23404372

PAPER Jahanshahi A, Vlamings R, Roon-Mom WV, Faull RL, Waldvogel HJ, Janssen ML, Yakkioui Y, Zeef D, Kocabicak E, Steinbusch HW, Temel Y

Changes in brainstem serotonergic and dopaminergic cell populations in experimental and clinical Huntington's disease.

Neuroscience. 2013 Feb 8; PubMed: 23403175

PAPER Gianforcaro A, Solomon JA, Hamadeh MJ

Vitamin D(3) at 50x AI attenuates the decline in paw grip endurance, but not disease outcomes, in the G93A mouse model of ALS, and is toxic in females.

PLoS One. 2013;8(2):e30243. PubMed: 23405058

PAPER Linares E, Seixas LV, Dos Prazeres JN, Ladd FV, Ladd AA, Coppi AA, Augusto O

Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms.

PLoS One. 2013;8(2):e55868. PubMed: 23405225

PAPER Bagchi DP, Yu L, Perlmutter JS, Xu J, Mach RH, Tu Z, Kotzbauer PT

Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.

PLoS One. 2013;8(2):e55031. PubMed: 23405108

PAPER Leung AY, Kwan CW, Chi I

Residents with Alzheimer's disease in long-term care facilities in Hong Kong: patterns of hospitalization and emergency room use.

Aging Ment Health. 2013 Feb 12; PubMed: 23402396

PAPER Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ, Wang JZ

Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model.

Neurobiol Aging. 2013 Jun;34(6):1555-63. Epub 2013 Feb 10 PubMed: 23402899

PAPER Rojas S, Herance JR, Gispert JD, Abad S, Torrent E, Jiménez X, Pareto D, Perpiña U, Sarroca S, Rodríguez E, Ortega-Aznar A, Sanfeliu C

In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography.

Neurobiol Aging. 2013 Jul;34(7):1790-8. PubMed: 23402900

PAPER Stevens CB, Hanna JM, Lammi RK

Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-β aggregation inhibitors.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1703-6. PubMed: 23403086