PAPER Kales HC, Zivin K, Kim HM, Valenstein M, Chiang C, Ignacio RV, Ignacio R, Ganoczy D, Cunningham F, Schneider LS, Blow FC
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331254 RESULTS
PAPER Ayalon L, Gum AM, Feliciano L, Areán PA
Effectiveness of nonpharmacological interventions for the management of neuropsychiatric symptoms in patients with dementia: a systematic review.
Arch Intern Med. 2006 Nov 13;166(20):2182-8. PubMed: 17101935PAPER Saad M, Cassagnol M, Ahmed E
The impact of FDA's warning on the use of antipsychotics in clinical practice: a survey.
Consult Pharm. 2010 Nov;25(11):739-44. PubMed: 21138822PAPER , Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Stefánsson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
Lancet. 2011 Feb 19;377(9766):641-9. PubMed: 21292315PAPER Conway CD, Howe KM, Nettleton NK, Price DJ, Mason JO, Pratt T
Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development.
J Neurosci. 2011 Feb 9;31(6):1955-70. PubMed: 21307234M. Flint Beal on Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.
COMMENT This is an impressive amount of work done by Dr. Yan and colleagues. The results strongly implicate a critical role for Aβ in mitochondria for AD pathogenesis. The finding that blocking the interaction of Aβ with Aβ peptide-binding alcohol dehydrogenase a
Hsc70 /Hsp73 (1B5)
ANTIBODY monoclonal 1B5 manufacturer SPA-815<br />Reference: <br /><a href="/papers/alpha-synuclein-promotes-snare-complex-assembly-vivo-and-vitro" target="_new">Burré J, 2010</a> immunogen = native hamster Hsc70 (Hsp73)
Russell Swerdlow on Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.
COMMENT In this paper, the Yan lab does a remarkable job following up on its seminal 2004 work that showed Aβ and an alcohol dehydrogenase associate within the mitochondria of mutant APP transgenic mice. The findings in this current paper reinforce the view that
PAPER Yao J, Du H, Yan S, Fang F, Wang C, Lue LF, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS
Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.
J Neurosci. 2011 Feb 9;31(6):2313-20. PubMed: 21307267Barry Boland on Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
COMMENT This paper by Tamboli et al. is an interesting study that highlights the increasing number of lysosomal storage diseases (LSDs) that have elevated amounts of APP-CTFs and Aβ, and indicates the importance of maintaining efficient lysosomal flux as an anti-
Hsc70 (1B5)
ANTIBODY monoclonal 1B5 manufacturer Cat# MA1-26078<br />Reference: <br /><a href="/papers/alpha-synuclein-promotes-snare-complex-assembly-vivo-and-vitro" target="_new">Burré J, 2010</a> immunogn = full length, native Hs
VGAT, cytoplasmic
ANTIBODY polyclonal manufacturer Cat# 131 003<br />Reference:<br /><a href="/papers/alpha-synuclein-promotes-snare-complex-assembly-vivo-and-vitro" target="_new">Burré J, 2010</a> Immunogen = synthetic peptide AEPPVEGDIH
Complexin-1,2
ANTIBODY polyclonal manufacturer Cat# 122002 immunogen = synthetic peptide KYLPGPLQDMFKK (aa 122- 134 in human) coupled to key-hole limpet hemocyanin via an added N-terminal cysteine residue antiserum, lyophilized. recognizes complexin 1 and 2 Synaptic Vesicle Fus
Syntaxin-1 (78.2)
ANTIBODY monoclonal 78.2 manufacturer Cat# 111011, purified, 111001, ascites<br />Reference: <br /><a href="/papers/alpha-synuclein-promotes-snare-complex-assembly-vivo-and-vitro" target="_new">Burré J, 2010</a> immunoge
Is Spinal Muscular Atrophy a Disease of Sensory Neurons?
RESEARCH NEWS 2011-02-11 Research News Far from being sick, motor neurons in a mouse model of spinal muscular atrophy are actually raring to fire. Unfortunately, they do not receive the signals telling them to do so. So conclude the authors of a paper in the February 10 Neuron. T
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