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331008 RESULTS
Virgil Muresan on Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.
COMMENT In this paper, Vagnoni et al. reassess the role of c-Jun N-terminal kinase (JNK)-interacting protein-1 (JIP-1) in the transport, phosphorylation, and amyloidogenic processing of Aβ precursor protein (APP). Specifically, they ask whether the axonal transpo
Sara Sanz-Blasco on Picomolar Amyloid-β Peptides Enhance Spontaneous Astrocyte Calcium Transients.
COMMENT This manuscript complements, in a very good way, work we recently published (Talantova et al., 2013),describing for first time the important role of astrocytic α7-nAChRs in Aβ amyloid calcium dysregulation and toxicity. 0 sarasanzb Aβ induces astrocytic g
PAPER Tagliavini F, Rossi G, Padovani A, Magoni M, Andora G, Sgarzi M, Bizzi A, Savoiardo M, Carella F, Morbin M, Giaccone G, Bugiani O
A new βPP mutation related to hereditary cerebral haemorrhage
Alzheimer's Rep, 1999;2(Suppl 1):S28.Simi Howard on Antibodies Stop Toxic Tau in Its Extracellular Tracks
COMMENT This is a very interesting paper. Regarding phosphorylated tau that has been shown to be secreted via various mechanisms from dendrites (e.g., via exosomes in association with proteins such as fyn), does anyone know whether the focal tau deposits immobili
Sanjay Pimplikar on More Evidence for AD Starting Without Brain Amyloid
COMMENT The significance of these findings, which now validate the phenomenon of SNAP, cannot be overstated. In 2009, based on the data then available, I suggested that amyloid is not the cause of AD, but a cause of AD (Pimplikar, 2009), and that amyloid-independ
PDGF-APPSw,Ind (line J9)
RESEARCH MODELS Summary Like the J20 mice, these mice over-express human APP with the Swedish and Indiana mutations. Transgene expression level is relatively low in J9 mice, approximately half the expression seen in J20 mice. Compared with J20 mice, J9 mice develop amylo
Arc48 (APPSw/Ind/Arc)
RESEARCH MODELS Modification Details A human APP minigene with the Swedish, Indiana, and Arctic mutations driven by the platelet-derived growth factor β-chain promoter. Neuropathology Parenchymal neuritic plaques by two months accompanied by dystrophic neurites. Prominen
Sara Shaheen on Galantamine population pharmacokinetics in patients with Alzheimer's disease: modeling and simulations.
COMMENT This is a good paper. 0 sara_shaheen665
Profilin-1 Links Cytoskeleton and RNA Aggregation in ALS
CONFERENCE COVERAGE 2013-11-20 Conference Coverage Several proteins linked to amyotrophic lateral sclerosis and frontotemporal dementia show up in stress granules. These natural RNA-protein accumulations protect essential RNAs in times of cellular strife, but cause trouble if they fail
Paper Alert: TDP-43 Mouse No Model to Test ALS Therapeutics
RESEARCH NEWS 2013-11-20 Research News In a paper in press in Brain Research, researchers have given one mouse model of TDP-43 proteinopathy a thumbs-down. While it was the first such mouse to be published (see Oct 2009 news story), it fails to mimic key features of amyotrophic l
PAPER Kerstein AH, Schroeder RW, Baade LE, Lincoln J, Khan AY
Frontotemporal dementia mimicking bipolar disorder.
J Psychiatr Pract. 2013 Nov;19(6):498-500. PubMed: 24241504PAPER Kahn DA
Commentary on cognitive and psychiatric symptoms associated with normal pressure hydrocephalus and frontotemporal dementia.
J Psychiatr Pract. 2013 Nov;19(6):505-7. PubMed: 24241506PAPER Riemensperger T, Issa AR, Pech U, Coulom H, Nguyễn MV, Cassar M, Jacquet M, Fiala A, Birman S
A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease.
Cell Rep. 2013 Nov 27;5(4):952-60. Epub 2013 Nov 14 PubMed: 24239353PAPER Hilton D, Stephens M, Kirk L, Edwards P, Potter R, Zajicek J, Broughton E, Hagan H, Carroll C
Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease.
Acta Neuropathol. 2014 Feb;127(2):235-41. Epub 2013 Nov 17 PubMed: 24240814Current Filters
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