Off BACE: Lack of Secretase Causes Seizures in Knockout Mice

RESEARCH NEWS 2010-07-04 Research News A potential therapeutic strategy for Alzheimer disease (AD) is to inhibit the β-secretase (BACE) enzymes that kickstart processing of amyloid precursor protein (APP) to form Aβ. BACE inhibitors are currently the subject of intense drug devel

PAPER Ren Z, Wang J, Zou C, Guan Y, Zhang YA

Comparative characterization of mesenchymal stem cells from different age groups of cynomolgus monkeys.

Sci China Life Sci. 2010 May;53(5):563-72. PubMed: 20596939

PAPER Cheng YQ, Xu J, Chai P, Li HJ, Luo CR, Yang T, Li L, Shan BC, Xu XF, Xu L

Brain volume alteration and the correlations with the clinical characteristics in drug-naïve first-episode MDD patients: a voxel-based morphometry study.

Neurosci Lett. 2010 Aug 9;480(1):30-4. PubMed: 20594947

ALS Gene Expression and Biomarkers: A Better Way to Microarray?

RESEARCH NEWS 2010-07-04 Research News Microarrays tantalize investigators with the promise of a new smorgasbord of genes to explore and proteins to target with therapeutics. But these studies are so variable, say researchers from the University of California, Los Angeles, David

PAPER Chatani E, Ohnishi R, Konuma T, Sakurai K, Naiki H, Goto Y

Pre-steady-state kinetic analysis of the elongation of amyloid fibrils of beta(2)-microglobulin with tryptophan mutagenesis.

J Mol Biol. 2010 Jul 30;400(5):1057-66. PubMed: 20595042

PAPER de Oliveira RM, Pais TF, Outeiro TF

Sirtuins: Common Targets in Aging and in Neurodegeneration.

Curr Drug Targets. 2010 Jul 1; PubMed: 20594174

PAPER Morikawa M, Kiuchi K, Taoka T, Nagauchi K, Kichikawa K, Kishimoto T

Uncinate fasciculus-correlated cognition in Alzheimer's disease: a diffusion tensor imaging study by tractography.

Psychogeriatrics. 2010 Mar;10(1):15-20. PubMed: 20594282

PAPER Hattori H, Yoshiyama K, Miura R, Fujie S

Clinical psychological tests useful for differentiating depressive state with Alzheimer's disease from major depression of the elderly.

Psychogeriatrics. 2010 Mar;10(1):29-33. PubMed: 20594284

PAPER Konishi K, Hori K, Uchida H, Watanabe K, Tominaga I, Kimura M, Hosoyamada M, Shibasaki T, Kataoka A, Hachisu M

Adverse effects of anticholinergic activity on cognitive functions in Alzheimer's disease.

Psychogeriatrics. 2010 Mar;10(1):34-8. PubMed: 20594285

PAPER Larson EB

Prospects for delaying the rising tide of worldwide, late-life dementias.

Int Psychogeriatr. 2010 Dec;22(8):1196-202. PubMed: 20594386

PAPER Davatzikos C, Bhatt P, Shaw LM, Batmanghelich KN, Trojanowski JQ

Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification.

Neurobiol Aging. 2011 Dec;32(12):2322.e19-27. PubMed: 20594615

PAPER Vacirca D, Delunardo F, Matarrese P, Colasanti T, Margutti P, Siracusano A, Pontecorvo S, Capozzi A, Sorice M, Francia A, Malorni W, Ortona E

Autoantibodies to the adenosine triphosphate synthase play a pathogenetic role in Alzheimer's disease.

Neurobiol Aging. 2010 Jun 29; PubMed: 20594618

PAPER Horiuchi M, Maezawa I, Itoh A, Wakayama K, Jin LW, Itoh T, Decarli C

Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro.

Neurobiol Aging. 2012 Mar;33(3):499-509. PubMed: 20594620

PAPER Mei Z, Situ B, Tan X, Zheng S, Zhang F, Yan P, Liu P

Cryptotanshinione upregulates alpha-secretase by activation PI3K pathway in cortical neurons.

Brain Res. 2010 Aug 12;1348:165-73. PubMed: 20595051

PAPER Wang YJ, Gao CY, Yang M, Liu XH, Sun Y, Pollard A, Dong XY, Wu XB, Zhong JH, Zhou HD, Zhou XF

Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer's disease.

Brain Behav Immun. 2010 Nov;24(8):1281-93. PubMed: 20595065