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Nature. 2010 Jun 24;465(7301):1070-4. PubMed: 20543823Kostas Vekrellis on Excess α-Synuclein Sends Synapses Sputtering
COMMENT α-synuclein and Synaptic Failure in PD α-synuclein has been biochemically and genetically linked to sporadic and familial PD. Mutations or multiplications of the α-synuclein gene cause familial forms of PD (Polymeropoulos et al., 1997; Krüger et al., 1998
Walter J. Schulz-Schaeffer on Excess α-Synuclein Sends Synapses Sputtering
COMMENT Both papers present evidence that the pathophysiological mechanism in synucleinopathies is not neuronal cell death but a synaptic dysfunction; that is very interesting. With regard to the clinical symptoms in PD, (also PDD and DLB), the synaptic pathology
Martin Ingelsson on Excess α-Synuclein Sends Synapses Sputtering
COMMENT The work by Scott and colleagues is of great interest as it is trying to pinpoint the molecular details in the synaptic pathology caused by a modest transgenic overexpression of α-synuclein. The authors found that PK-resistant and abnormally phosphorylate
Robert Edwards on Excess α-Synuclein Sends Synapses Sputtering
COMMENT The background for our work is that α-synuclein normally localizes to the axon terminal of essentially all neurons, but its role, if any, in neurotransmitter release has remained very unclear. In general, knockout mice have shown either no effect or confl
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