Aβ fibrils (WO1)

ANTIBODY monoclonal WO1 laboratory raised against sonicated amyloid fibrils grown from synthesized Aβ1–40 peptides (epitope within aa 1-16) detects amyloid-beta fibrils; exhibits binding to fibrils in the presence of a large excess of Aβ(1–40) monomer, suggesting

PAPER Matsumoto S, Goto S, Kusaka H, Imai T, Murakami N, Hashizume Y, Okazaki H, Hirano A

Ubiquitin-positive inclusion in anterior horn cells in subgroups of motor neuron diseases: a comparative study of adult-onset amyotrophic lateral sclerosis, juvenile amyotrophic lateral sclerosis and Werdnig-Hoffmann disease.

J Neurol Sci. 1993 Apr;115(2):208-13. PubMed: 8387100

PAPER Munoz DG

FUS mutations in sporadic juvenile ALS: another step toward understanding ALS pathogenesis.

Neurology. 2010 Aug 17;75(7):584-5. PubMed: 20668260

PAPER Huang EJ, Zhang J, Geser F, Trojanowski JQ, Strober JB, Dickson DW, Brown RH, Shapiro BE, Lomen-Hoerth C

Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions.

Brain Pathol. 2010 Nov;20(6):1069-76. PubMed: 20579074

PAPER Gouveia LO, de Carvalho M

Young-onset sporadic amyotrophic lateral sclerosis: a distinct nosological entity?

Amyotroph Lateral Scler. 2007 Dec;8(6):323-7. PubMed: 17852021

Research Brief: FUS Rears Its Head in Juvenile ALS, Too

RESEARCH NEWS 2010-08-08 Research News Amyotrophic lateral sclerosis is tragic when it hits in late or middle age, but a rare juvenile form of the disease is all the more devastating because it attacks people in their late teens and early twenties. “Juvenile ALS is a relatively o

Paper Alert: Grappling Globulomers Improves Mouse Cognition

RESEARCH NEWS 2010-08-08 Research News Antibodies to synthetic Aβ oligomers, or “globulomers,” improve cognition in a mouse model of Alzheimer disease, according to a paper in yesterday’s Journal of Neuroscience. Scientists led by Heinz Hillen and Ulrich Ebert at Abbot, Ludwigsha

PAPER Brunette KE, Tran PV, Wobken JD, Carlson ES, Georgieff MK

Gestational and neonatal iron deficiency alters apical dendrite structure of CA1 pyramidal neurons in adult rat hippocampus.

Dev Neurosci. 2010 Aug;32(3):238-48. PubMed: 20689287

PAPER He Q, Song N, Xu H, Wang R, Xie J, Jiang H

Alpha-synuclein aggregation is involved in the toxicity induced by ferric iron to SK-N-SH neuroblastoma cells.

J Neural Transm. 2011 Mar;118(3):397-406. PubMed: 20690031

PAPER Tselis A, Khan OA, Lisak RP

Approaches to neuroprotective strategies in multiple sclerosis.

Expert Opin Pharmacother. 2010 Dec;11(17):2869-78. PubMed: 20687779

PAPER Machado I, González P, Schiöth HB, Lasaga M, Scimonelli TN

α-Melanocyte-stimulating hormone (α-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions.

Peptides. 2010 Nov;31(11):2141-4. PubMed: 20688120

PAPER Wang T, Fu FH, Han B, Zhang LM, Zhang XM

Long-term but not short-term aspirin treatment attenuates diabetes-associated learning and memory decline in mice.

Exp Clin Endocrinol Diabetes. 2011 Jan;119(1):36-40. PubMed: 20690072

PAPER Maximova OA, Murphy BR, Pletnev AG

High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence.

Vaccine. 2010 Dec 6;28(52):8315-26. PubMed: 20688036

PAPER Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons.

Cell Death Differ. 2011 Feb;18(2):282-92. PubMed: 20689558

PAPER Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G

Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA).

Adv Exp Med Biol. 2010;685:64-74. PubMed: 20687495