COMMENT The PS1 gene appears to be a FAD mutation hot spot: More than 200 mutations have been identified (PSEN1 mutations). Does anyone know why? The age of onset varies from 30 to 60. In comparison, the number of APP mutations is smaller (APP mutations), ...
JOB 2016-05-06 Employer The Biodesign Institute, Neurodegenerative Research Center Principal Investigator Salvatore Oddo Description The research associate will conduct research in molecular and behavioral alterations in animal models of Alzheimer's disease and ...
COMMENT In this paper, Dr. Lui and co-workers demonstrated that progranulin (PGRN) deficiency facilitated synaptic pruning resulting from increased C1qa production in cultured microglia and in mice. PGRN haploinsufficiency, resulting from a heterozygous mutation ...
RESEARCH NEWS 2016-05-06 Research News Scientists and clinicians gathered at the University of Southern California in Los Angeles on April 15, 2016, for a day jam-packed with a dozen presentations. It was the third annual Zilkha Symposium on Alzheimer Disease & Related ...
PAPER von Schantz C, Kielar C, Hansen SN, Pontikis CC, Alexander NA, Kopra O, Jalanko A, Cooper JD
Progressive thalamocortical neuron loss in Cln5 deficient mice: Distinct effects in Finnish variant late infantile NCL.Neurobiol Dis. 2009 May;34(2):308-19. PubMed: 19385065
PAPER Kielar C, Maddox L, Bible E, Pontikis CC, Macauley SL, Griffey MA, Wong M, Sands MS, Cooper JD
Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis.Neurobiol Dis. 2007 Jan;25(1):150-62. Epub 2006 Oct 12 PubMed: 17046272
PAPER Liu M, Bachstetter AD, Cass WA, Lifshitz J, Bing G
Pioglitazone attenuates neuroinflammation and promotes dopaminergic neuronal survival in the nigrostriatal system of rats after diffuse brain injury.J Neurotrauma. 2016 May 3; PubMed: 27142118
PAPER Turner A, Eccles F, Keady J, Simpson J, Elvish R27141988
PAPER Zaman M, Zakariya SM, Nusrat S, Khan MV, Qadeer A, Ajmal MR, Khan RH27141925
PAPER Bertolin C, Querin G, Da Re E, Sagnelli A, Bello L, Cao M, Muscas M, Pennuto M, Ermani M, Pegoraro E, Mariotti C, Gellera C, Hanna MG, Pareyson D, Fratta P, Sorarù G27141859
PAPER Möller JC, Menig A, Oechsner M27005731
PAPER Sugama S, Kakinuma Y
Loss of Dopaminergic neurons occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: possible pathogenetic loci for depression involved in Parkinson's disease.Neurosci Res. 2016 Apr 30; PubMed: 27142317
PAPER Matute MS, Matute R, Merino P27142290
PAPER Kim H, Kim SH, Cha H, Kim SR, Lee JH, Park JW
IDH2 deficiency promotes mitochondrial dysfunction and dopaminergic neurotoxicity: implications for Parkinson's disease.Free Radic Res. 2016 May 4;:1-18. PubMed: 27142242
PAPER Almeida S, Gao F, Coppola G, Gao FB
Suberoylanilide hydroxamic acid increases progranulin production in iPSC-derived cortical neurons of frontotemporal dementia patients.Neurobiol Aging. 2016 Jun;42:35-40. Epub 2016 Mar 9 PubMed: 27143419
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