CONFERENCE COVERAGE 2016-02-10 Conference Coverage The accumulation of tau protein in the brain reflects a spectrum of different human neurodegenerative diseases, from those affecting the front of the brain, such as frontotemporal dementia, to those affecting the back, such as ...
Huddersfield, United Kingdom
RESEARCH NEWS 2016-02-09 Research News A kinase inhibitor that is an approved medication for people and improves memory in rats also promotes degradation of toxic tau in lab models, according to a paper in the January 27 Journal of Neuroscience. Inhibiting the Rho-associated ...
PAPER Huentelman MJ, Stephan DA, Talboom J, Corneveaux JJ, Reiman DM, Gerber JD, Barnes CA, Alexander GE, Reiman EM, Bimonte-Nelson HA19170447
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PAPER Enomoto Y, Yoshimura S, Yamada K, Iwama T
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PAPER Shi J, Wei L23921309
COMMENT I would like to thank Dr. Trushina for her comment, while also pointing out that our methods for sample collection, processing, and storage are outlined in the supplemental material of our manuscript. I direct the Alzforum audience's attention to the ...
Gerd Pfeifer on Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.
COMMENT I agree with the comments on Jin et al (2016). The binding of this Tet3 isoform to lysosomal and autophagy genes is quite specific. There must be a selective recruitment process. We are now studying Tet3 localization and function in young and aging brain ...
Cedars-Sinai Medical CenterLos Angeles
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