PAPER Dong H, Mao S, Wei J, Liu B, Zhang Z, Zhang Q, Yan M
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PAPER Hur JY, Teranishi Y, Kihara T, Yamamoto NG, Inoue M, Hosia W, Hashimoto M, Winblad B, Frykman S, Tjernberg LO
Identification of Novel γ-Secretase-associated Proteins in Detergent-resistant Membranes from Brain.
J Biol Chem. 2012 Apr 6;287(15):11991-2005. PubMed: 22315232PAPER Silveira de Souza A, de Oliveira-Souza R, Moll J, Tovar-Moll F, Andreiuolo PA, Bottino CM
Contribution of 1H spectroscopy to a brief cognitive-functional test battery for the diagnosis of mild Alzheimer's disease.
Dement Geriatr Cogn Disord. 2011;32(5):351-61. PubMed: 22311276PAPER Shilling D, Mak DO, Kang DE, Foskett JK
Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.
J Biol Chem. 2012 Mar 30;287(14):10933-44. PubMed: 22311977PAPER Morris JC
Revised Criteria for Mild Cognitive Impairment May Compromise the Diagnosis of Alzheimer Disease Dementia.
Arch Neurol. 2012 Feb 6; PubMed: 22312163PAPER Butterfield DA, Sultana R
Methionine-35 of aβ(1-42): importance for oxidative stress in Alzheimer disease.
J Amino Acids. 2011;2011:198430. PubMed: 22312456PAPER Mioshi E, Foxe D, Leslie F, McLinneuro SS, Hsieh S, Miller L, Hodges JR, Piguet O
The Impact of Dementia Severity on Caregiver Burden in Frontotemporal Dementia and Alzheimer Disease.
Alzheimer Dis Assoc Disord. 2012 Feb 6; PubMed: 22314247PAPER De Strooper B, Iwatsubo T, Wolfe MS
Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease.
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006304. PubMed: 22315713PAPER Wyss-Coray T, Rogers J
Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature.
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006346. PubMed: 22315714PAPER Selkoe D, Mandelkow E, Holtzman D
Deciphering Alzheimer disease.
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a011460. PubMed: 22315723PAPER Hur EM, Zhou FQ
GSK3 signalling in neural development.
Nat Rev Neurosci. 2010 Aug;11(8):539-51. PubMed: 20648061Jürgen Götz on Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations.
COMMENT This is an interesting paper. However, 3R-tau, which has only one cysteine, is not mentioned at all, and in AD, both 4R and 3R tau form aggregates. It might be interesting in subsequent studies to include a 3R truncated form similar to the K18 construct.
Juan Domingo Gispert
Fundació Pasqual MaragallBarcelona, Spain
Paper Alert: γ-Secretase Modulators Trump Inhibitors
RESEARCH NEWS 2012-02-09 Research News A paper in the February 8 Journal of Neuroscience reports that γ-secretase inhibitors do nothing to improve memory in AD mice when given subchronically, and can even worsen cognition in normal mice. By contrast, under the same conditions a γ
Beyond Aβ: Other APP Fragments Affect Neuron Health and Disease
RESEARCH NEWS 2012-02-09 Research News In Alzheimer’s research, Aβ usually hogs the attention from its parent protein, amyloid precursor protein (APP). Yet evidence is accumulating that other APP fragments, particularly those produced by β-secretase (BACE1) cleavage, such as β-CT
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