MAPT L315L

MUTATIONS MAPT 44091638 GRCh37/hg19 rs63751231 G A g.127673G> A g.124852G> A Exon 11 Point, Silent Coding Unknown. Unknown. L315L Frontotemporal Dementia: Not ClassifiedFrontotemporal Dementia Little is known about this silent mutation, but it has been mentio

MAPT L315R

MUTATIONS MAPT 44091637 GRCh37/hg19 rs63749855 T G g.127672T> G g.124851T> G Exon 11 Point, Missense Coding Recombinant L315R tau protein has a compromised ability to promote microtubule assembly. Extensive tau pathology in neurons (Pick-like inclusions) and

Satori Pharmaceuticals Shuts Down, Abandons γ-Secretase Modulators

RESEARCH NEWS 2013-06-07 Research News Satori Pharmaceuticals, which had been developing γ-secretase modulators for the treatment of Alzheimer's disease, has closed its doors, according to a news report. Satori representatives were not available for comment. In July 2012, th

Brain Changes Speak Volumes About Normal Aging and Dementia

RESEARCH NEWS 2013-06-07 Research News Brain atrophy plagues more than just people with neurodegenerative disorders. Even seemingly healthy individuals lose brain matter over time. Can doctors and researchers separate brain changes due to Alzheimer's disease and other dement

Newborn Neurons Abundant in Adult Human Hippocampus

RESEARCH NEWS 2013-06-07 Research News Scientists know that the adult human brain makes new neurons, but they debate whether those fledgling cells have a functional role. Now, using carbon-14 to estimate the age of neurons, researchers led by Jonas Frisén, Karolinska Institutet,

PAPER Li NN, Mao XY, Chang XL, Zhao DM, Zhang JH, Liao Q, Yu WJ, Tan EK, Peng R

SNCA rs356219 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.

Am J Med Genet B Neuropsychiatr Genet. 2013 Jul;162B(5):452-6. PubMed: 23737253

PAPER Zheng D, Jiang X, Zhao J, Duan D, Zhao H, Xu Q

Subthalamic hGAD65 gene therapy and striatum TH gene transfer in a Parkinson's disease rat model.

Neural Plast. 2013;2013:263287. PubMed: 23738148

PAPER Xie P, Yu T, Fu X, Tu Y, Zou Y, Lui S, Zhao X, Huang X, Kemp GJ, Gong Q

Altered functional connectivity in an aged rat model of postoperative cognitive dysfunction: a study using resting-state functional MRI.

PLoS One. 2013;8(5):e64820. PubMed: 23738003

PAPER Apolloni S, Amadio S, Montilli C, Volonté C, D'Ambrosi N

Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.

Hum Mol Genet. 2013 Jun 13; PubMed: 23736299

PAPER Loizzo S, Rimondini R, Travaglione S, Fabbri A, Guidotti M, Ferri A, Campana G, Fiorentini C

CNF1 increases brain energy level, counteracts neuroinflammatory markers and rescues cognitive deficits in a murine model of Alzheimer's disease.

PLoS One. 2013;8(5):e65898. PubMed: 23738020

PAPER Swarup V, Srivastava AK, Padma MV, Moganty RR

Quantitative Profiling and Identification of Plasma Proteins of Spinocerebellar Ataxia Type 2 Patients.

Neurodegener Dis. 2013 May 31; PubMed: 23735416

PAPER Liot G, Zala D, Pla P, Mottet G, Piel M, Saudou F

Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.

J Neurosci. 2013 Apr 10;33(15):6298-309. PubMed: 23575829

PAPER Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC

The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models.

J Neurosci. 2013 Apr 10;33(15):6557-62. PubMed: 23575853

PAPER Vukovic J, Borlikova GG, Ruitenberg MJ, Robinson GJ, Sullivan RK, Walker TL, Bartlett PF

Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering.

J Neurosci. 2013 Apr 10;33(15):6603-13. PubMed: 23575857

PAPER Zhang Q, Du X, Xu Y, Dang L, Xiang L, Zhang J

The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease.

Exp Ther Med. 2013 May;5(5):1528-1530. PubMed: 23737913