PAPER Tanaka K, Wada I, Okunomiya T, Shima A, Kambe D, Shinde A, Kageyama T, Suenaga T
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PAPER Kamaraj B, Rajendran V, Sethumadhavan R, Vinay Kumar CH, Purohit R
Mutational analysis of FUS gene and its structural and functional role in Amyotrophic lateral sclerosis 6.
J Biomol Struct Dyn. 2014 Apr 16;:1-35. PubMed: 24738488PAPER Hwang M, Lee JM, Kim Y, Geum D
Functional Role of Parkin against Oxidative Stress in Neural Cells.
Endocrinol Metab (Seoul). 2014 Mar;29(1):62-9. Epub 2014 Mar 14 PubMed: 24741456PAPER Chikina MD, Sealfon SC
Increasing consistency of disease biomarker prediction across datasets.
PLoS One. 2014;9(4):e91272. Epub 2014 Apr 16 PubMed: 24740471PAPER Brown D, Tamas A, Reglodi D, Tizabi Y
PACAP Protects Against Inflammatory-Mediated Toxicity in Dopaminergic SH-SY5Y Cells: Implication for Parkinson's Disease.
Neurotox Res. 2014 Apr 17; PubMed: 24740430PAPER Genin GM
Nanoscopic injury with macroscopic consequences: tau proteins as mediators of diffuse axonal injury.
Biophys J. 2014 Apr 15;106(8):1551-2. PubMed: 24739151Olav Andersen
Aarhus UniversityDenmark
Anthony Perugini
Polymer engineering
Marc Diamond on Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.
COMMENT I think this is a very carefully done study, and the authors are to be congratulated. The authors confirm some essential observations that have been made by others regarding the injection of α-synuclein seeds into mouse brain. However, they have appropria
PAPER Wood SJ, Wypych J, Steavenson S, Louis JC, Citron M, Biere AL
alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.
J Biol Chem. 1999 Jul 9;274(28):19509-12. PubMed: 10391881Are Synuclein Seeds Non-Starters?
RESEARCH NEWS 2014-04-18 Research News Just because you plant some seeds doesn’t mean they’ll grow. In the case of the α-synuclein protein thought to seed toxic aggregates in Parkinson’s disease, the brains of non-transgenic mice failed to provide fertile soil, according to recen
Down’s Syndrome Loosens Regulation of the Entire Genome
RESEARCH NEWS 2014-04-18 Research News For decades, scientists thought that Down’s syndrome resulted from genes carried on the extra copy of chromosome 21 that causes the disorder. More recently, researchers have recognized that gene expression becomes altered throughout the enti
Santiago Sole-Domenech
Weill Cornell MedicineNew York City, United States
PAPER Hibaoui Y, Grad I, Letourneau A, Sailani MR, Dahoun S, Santoni FA, Gimelli S, Guipponi M, Pelte MF, Béna F, Antonarakis SE, Feki A
Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21.
EMBO Mol Med. 2014 Feb;6(2):259-77. Epub 2013 Dec 27 PubMed: 24375627PAPER Hansen RS, Thomas S, Sandstrom R, Canfield TK, Thurman RE, Weaver M, Dorschner MO, Gartler SM, Stamatoyannopoulos JA
Sequencing newly replicated DNA reveals widespread plasticity in human replication timing.
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):139-44. Epub 2009 Dec 4 PubMed: 19966280Current Filters
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