PAPER McMillan PJ, Kraemer BC, Robinson L, Leverenz JB, Raskind M, Schellenberg G
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PAPER Wallin AK, Wattmo C, Minthon L
Galantamine treatment in Alzheimer's disease: response and long-term outcome in a routine clinical setting.
Neuropsychiatr Dis Treat. 2011;7:565-76. PubMed: 22003296Rakez Kayed on Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition.
COMMENT This well-designed study is an extension of the previous outstanding studies published by Jucker's group on amyloid induction in vivo. In my opinion, it represents a significant step, fortunately, in the right direction. It clearly demonstrates that
Randall Bateman on Sleep and waking modulate spine turnover in the adolescent mouse cortex.
COMMENT Giulio Tononi's findings may or may not be related to the findings in humans of circadian Aβ levels. One hypothesis is that increasing spine and synaptic strength during wakefulness leads to increased Aβ production via increased synaptic activity. Co
Philip Scheltens on The EMA Deems Brain Atrophy Valid Trial Selection Measure
COMMENT I applaud the EMA for taking this, and the previous, initiative, since they clearly may boost industry to use these markers in future clinical trials. Further, both EMA guidelines clearly underline the rationale of the concept reflected in the Dubois set
PAPER Alzualde A, Moreno F, Martínez-Lage P, Ferrer I, Gorostidi A, Otaegui D, Blázquez L, Atares B, Cardoso S, Martínez de Pancorbo M, Juste R, Rodríguez-Martínez AB, Indakoetxea B, López de Munain A
Somatic mosaicism in a case of apparently sporadic Creutzfeldt-Jakob disease carrying a de novo D178N mutation in the PRNP gene.
Am J Med Genet B Neuropsychiatr Genet. 2010 Oct 5;153B(7):1283-91. PubMed: 20872767PAPER Lashuel HA, Aljabari B, Sigurdsson EM, Metz CN, Leng L, Callaway DJ, Bucala R
Amyloid fibril formation by macrophage migration inhibitory factor.
Biochem Biophys Res Commun. 2005 Dec 16;338(2):973-80. PubMed: 16286092PAPER Vanderperre B, Staskevicius AB, Tremblay G, McCoy M, O'Neill MA, Cashman NR, Roucou X
An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.
FASEB J. 2011 Jul;25(7):2373-86. PubMed: 21478263PAPER Wills PR, Hughes AJ
Stem loops in HIV and prion protein mRNAs.
J Acquir Immune Defic Syndr. 1990;3(2):95-7. PubMed: 1967310PAPER Scheffer U, Okamoto T, Forrest JM, Rytik PG, Müller WE, Schröder HC
Interaction of 68-kDa TAR RNA-binding protein and other cellular proteins with prion protein-RNA stem-loop.
J Neurovirol. 1995 Dec;1(5-6):391-8. PubMed: 9222382PAPER Lück R, Steger G, Riesner D
Thermodynamic prediction of conserved secondary structure: application to the RRE element of HIV, the tRNA-like element of CMV and the mRNA of prion protein.
J Mol Biol. 1996 May 24;258(5):813-26. PubMed: 8637012PAPER Baringer JR, Prusiner SB
Experimental scrapie in mice: ultrastructural observations.
Ann Neurol. 1978 Sep;4(3):205-11. PubMed: 568909PAPER Bândea CI
From prions to prionic viruses.
Med Hypotheses. 1986 Jun;20(2):139-42. PubMed: 3090406PAPER Kagan BL
Antimicrobial amyloids?
Biophys J. 2011 Apr 6;100(7):1597-8. PubMed: 21463571PAPER Kuwabara S, Yokota T
Propagation: prion-like mechanisms can explain spreading of motor neuronal death in amyotrophic lateral sclerosis?
J Neurol Neurosurg Psychiatry. 2011 Nov;82(11):1181-2. PubMed: 21921086Current Filters
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