Grace Stutzmann on Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.

COMMENT The prominence of early/pre-symptomatic calcium signaling disruptions in mutant presenilin (PS)-expressing neurons has been well established in the AD field, but to fortify relevance to the disease process, dysregulated calcium still needs to be transduce

Ellen Melbye Langballe

Norwegian Institute of Public Health
Oslo, Norway

Jeroen Schuermans

Belgium

Hainuo Cheng

Shenzhen, China

Bin Li

LSU Health Science Center-Shreveport
Shreveport, United States

Paris: President and All, French Science Takes the Stage

CONFERENCE COVERAGE 2011-08-03 Conference Coverage Luc Buée of the University of Lille was one of the few tauists among the plenary speakers at this year’s Alzheimer’s Association International Conference (AAIC), held 16-21 July 2011 in Paris. But he did not get a chance to tell the wh

Vania Broccoli on Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.

COMMENT This paper by Kaspar and colleagues aimed to accelerate the generation of motor neurons from induced pluripotent stem (iPS) cells. Indeed, this is currently a bottleneck for all stem cell biologists interested in using iPS-derived motor neurons for in-vit

PAPER Borghero G, Floris G, Cannas A, Marrosu MG, Murru MR, Costantino E, Parish LD, Pugliatti M, Ticca A, Traynor BJ, Calvo A, Cammarosano S, Moglia C, Cistaro A, Brunetti M, Restagno G, Chiò A

A patient carrying a homozygous p.A382T TARDBP missense mutation shows a syndrome including ALS, extrapyramidal symptoms, and FTD.

Neurobiol Aging. 2011 Dec;32(12):2327.e1-5. PubMed: 21803454

PAPER Ahmed A, Wicklund MP

Amyotrophic lateral sclerosis: what role does environment play?

Neurol Clin. 2011 Aug;29(3):689-711. PubMed: 21803219

PAPER Martins T, Baptista S, Gonçalves J, Leal E, Milhazes N, Borges F, Ribeiro CF, Quintela O, Lendoiro E, López-Rivadulla M, Ambrósio AF, Silva AP

Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: role of tight junction proteins and matrix metalloproteinase-9.

Brain Res. 2011 Sep 9;1411:28-40. PubMed: 21803344

PAPER Ullah N, Naseer MI, Ullah I, Lee HY, Koh PO, Kim MO

Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain.

Neuropharmacology. 2011 Dec;61(8):1248-55. PubMed: 21803053

PAPER Jiang H, Tian X, Guo Y, Duan W, Bu H, Li C

Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity.

Biol Pharm Bull. 2011;34(8):1194-7. PubMed: 21804205

PAPER Otto M, Ludolph AC, Landwehrmeyer B, Förstl H, Diehl-Schmid J, Neumann M, Kretzschmar HA, Schroeter M, Kornhuber J, Danek A,

[German consortium for frontotemporal lobar degeneration].

Nervenarzt. 2011 Aug;82(8):1002-5. PubMed: 21805118

PAPER Moore RA, Timmes AG, Wilmarth PA, Safronetz D, Priola SA

Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure.

Proteomics. 2011 Oct;11(19):3853-65. PubMed: 21805638

PAPER Rhodes RE, Temple VA, Tuokko HA

Evidence-based risk assessment and recommendations for physical activity clearance: cognitive and psychological conditions (1) (1) This paper is one of a selection of papers published in this Special Issue, entitled Evidence-based risk assessment and reco

Appl Physiol Nutr Metab. 2011 Jul;36 Suppl 1:S113-53. PubMed: 21800939