PAPER Zahodne LB, Manly JJ, Mackay-Brandt A, Stern Y

Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.

PLoS One. 2013;8(9):e73645. PubMed: 24023894

PAPER Hardas SS, Sultana R, Clark AM, Beckett TL, Szweda LI, Murphy MP, Butterfield DA

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain.

Redox Biol. 2013;1(1):80-5. PubMed: 24024140

PAPER Ventriglia M, Zanardini R, Bonomini C, Zanetti O, Volpe D, Pasqualetti P, Gennarelli M, Bocchio-Chiavetto L

Serum brain-derived neurotrophic factor levels in different neurological diseases.

Biomed Res Int. 2013;2013:901082. PubMed: 24024214

PAPER Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16562-7. PubMed: 24023061

Vincent Coppola

Bowling Green State University; J.P. Scott Center for Neuroscience, Mind, & Behavior
Bowling Green, United States

Sherry Willis on Video game training enhances cognitive control in older adults.

COMMENT This is a well-designed video game training study reporting improvement in cognitive control in older adults. It was conducted by a well-established and respected group of investigators. The findings, as the authors acknowledge, are preliminary, given the

Linday Hixson

UNC Greensboro
GREENSBORO, United States

PAPER Anguera JA, Boccanfuso J, Rintoul JL, Al-Hashimi O, Faraji F, Janowich J, Kong E, Larraburo Y, Rolle C, Johnston E, Gazzaley A

Video game training enhances cognitive control in older adults.

Nature. 2013 Sep 5;501(7465):97-101. PubMed: 24005416

Michelle Mielke on Loss of Fornix White Matter Volume as a Predictor of Cognitive Impairment in Cognitively Normal Elderly Individuals.

COMMENT This is not the first longitudinal study to examine the fornix as a predictor of MCI in cognitively normal elderly. Zhuang and colleagues also reported that cognitively normal individuals who developed amnestic MCI had lower fornix fractional anisotropy (

PSEN1(M146V) Knock-In

RESEARCH MODELS Summary These mice expresses human PSEN1 with the M146V mutation, which is associated with familial Alzheimer's disease. These mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous mice

PAPER Costa AC, Stasko MR, Schmidt C, Davisson MT

Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).

Behav Brain Res. 2010 Jan 5;206(1):52-62. Epub 2009 Aug 29 PubMed: 19720087

SAR228810

THERAPEUTICS Sanofi Immunotherapy (passive) Amyloid-Related From 2012-2015, a multicenter Phase 1 trial tested six ascending doses of intravenous infusion and two doses of subcutaneous injection on safety, pharmacokinetics, and pharmacodynamic endpoints in 48 patients

Octagam®10%

THERAPEUTICS Octapharma Intravenous Immunoglobulin NewGam Immunotherapy (passive) Amyloid-Related Inflammation The first trial of this IVIG preparation in Alzheimer's evaluated six different doses of Octagam 10 percent against two placebo comparators in a six-mon

Gamunex

THERAPEUTICS Grifols Biologicals Inc. Intravenous Immunoglobulin Human Albumin Combined With Flebogamma Combination Immunotherapy (passive) Amyloid-Related Inflammation A multicenter Phase 2/3 trial being conducted in Spain is comparing three doses of 5 percent human

PAPER Wong CC, Wallhagen MI

Family Caregivers of Individuals with Frontotemporal Dementia: Examining the Relationship Between Coping and Caregiver Physical and Mental Health.

J Gerontol Nurs. 2013 Sep 4;:1-11. PubMed: 24015887