RESEARCH NEWS 2015-05-29 Research News One must know oneself and one's enemy to prevail in battle, according to the legendary militarist Sun Tzu. The first shot in the war against amyloid was fired long ago, but researchers are still getting to know which species of Aβ pose ...
COMMENT CALM/PICALM is one of the most abundant clathrin adaptors in endocytic clathrin-coated vesicles and regulates the endocytic process at presynaptic active zones of neurons (Blondeau et al., 2004; Koo et al., 2011). Regarding the pathological aspect of ...
RESEARCH NEWS 2015-05-29 Research News Genome-wide association studies have fingered PICALM as a consistent link to Alzheimer’s disease. The protein promotes clathrin-mediated endocytosis and has been tied to APP processing and increased Aβ production in neurons. In the May 25 ...
PAPER Miller SE, Mathiasen S, Bright NA, Pierre F, Kelly BT, Kladt N, Schauss A, Merrifield CJ, Stamou D, Höning S, Owen DJ
CALM Regulates Clathrin-Coated Vesicle Size and Maturation by Directly Sensing and Driving Membrane Curvature.Dev Cell. 2015 Apr 20;33(2):163-75. PubMed: 25898166
PAPER Koo SJ, Markovic S, Puchkov D, Mahrenholz CC, Beceren-Braun F, Maritzen T, Dernedde J, Volkmer R, Oschkinat H, Haucke V
SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13540-5. Epub 2011 Aug 1 PubMed: 21808019
PAPER Blondeau F, Ritter B, Allaire PD, Wasiak S, Girard M, Hussain NK, Angers A, Legendre-Guillemin V, Roy L, Boismenu D, Kearney RE, Bell AW, Bergeron JJ, McPherson PS
Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling.Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3833-8. Epub 2004 Mar 8 PubMed: 15007177
PAPER Roberts KF, Elbert DL, Kasten TP, Patterson BW, Sigurdson WC, Connors RE, Ovod V, Munsell LY, Mawuenyega KG, Miller-Thomas MM, Moran CJ, Cross DT 3rd, Derdeyn CP, Bateman RJ25205593
PAPER Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.Blood. 2010 Jun 10;115(23):4963-72. Epub 2010 Mar 26 PubMed: 20348395
PAPER Siemers E, Dean RA, DeMattos RB, Hutton ML, Blennow K, Shaw LM, Holtzman DM
Anti-Aβ antibody target engagement: commentary regarding Watt et al. Acta Neuropathol 127:803-810 (2014).Acta Neuropathol. 2014 Oct;128(4):609-10. Epub 2014 Aug 14 PubMed: 25120192
COMMENT We found that the A713T mutation segregated with disease in a large Italian family, strongly supporting the pathogenicity of this rare variant (Conidi et al., 2015). However, this mutation did not segregate with disease in a previously described family ...
PAPER Berleant D, White M, Pierce E, Tudoreanu E, Boeszoermenyi A, Shtridelman Y, Macosko JC19639425
Regional Neurogenetic CentreLamezia terme, Italy
Regional Neurogenetic CentreLamezia Terme, Italy
PAPER Potts LF, Park ES, Woo JM, Dyavar Shetty BL, Singh A, Braithwaite SP, Voronkov M, Papa SM, Mouradian MM
Dual κ-agonist/μ-antagonist opioid receptor modulation reduces levodopa-induced dyskinesia and corrects dysregulated striatal changes in the nonhuman primate model of Parkinson disease.Ann Neurol. 2015 Jun;77(6):930-41. Epub 2015 Mar 27 PubMed: 25820831
No filters selected