PAPER Romero-Corral A, Caples SM, Lopez-Jimenez F, Somers VK20202954
Fajardo, Puerto Rico
Brigham and Women's HospitalBoston, United States
PAPER Zhou X, Paushter DH, Feng T, Sun Li, Reinheckel T, Hu F
Federal University of Rio de JaneiroRio de Janeiro, Brazil
Thomas Kukar, Christopher Holler on Granulins: The Missing Link between Progranulin and Lysosome Function?
COMMENT The paper from Xiaolai Zhou et al. in Fenhua Hu's lab further supports the hypothesis that intracellular progranulin is processed into mature granulins in the lysosomal pathway. They demonstrate that modulation of cathepsin expression or ...
PAPER Holler CJ, Taylor G, Deng Q, Kukar T
PAPER Chang MC, Srinivasan K, Friedman BA, Suto E, Modrusan Z, Lee WP, Kaminker JS, Hansen DV, Sheng M28778989
COMMENT Tau Packs Heat No doubt tau protein is the culprit in its namesake diseases—the tauopathies, which include Alzheimer’s disease. Among the longstanding head-scratching problems in tau pathobiology is how tau, one of the most soluble proteins known, ...
COMMENT This study has addressed a salient issue in human astrocyte biology. It nicely confirms and extends a previous study by the Barres Lab (Zhang et al., 2016), which characterized purified astrocytes from fetal through to adult stages. It chronicles the ...
PAPER Knowles RB, Sabry JH, Martone ME, Deerinck TJ, Ellisman MH, Bassell GJ, Kosik KS8987809
PAPER Das RK, Pappu RV
Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues.Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13392-7. Epub 2013 Jul 30 PubMed: 23901099
COMMENT This is an interesting study that has prompted a lot of discussion among both scientists and patients. It is a relatively small-scale trial, and enrolled people with moderate to advanced PD who were already on levodopa and a number of other medications. ...
COMMENT This Dilan Athauda/Tom Foltynie Lancet article evaluating the GLP-1 agonist exenatide in Parkinson’s disease (PD) patients in a randomized, double-blind, placebo-controlled trial provides a highly promising finding, in that this approved Type 2 diabetes ...
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