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Arc48 (APPSw/Ind/Arc)

RESEARCH MODELS Modification Details A human APP minigene with the Swedish, Indiana, and Arctic mutations driven by the platelet-derived growth factor β-chain promoter. Neuropathology Parenchymal neuritic plaques by two months accompanied by dystrophic neurites. Prominen

Profilin-1 Links Cytoskeleton and RNA Aggregation in ALS

CONFERENCE COVERAGE 2013-11-20 Conference Coverage Several proteins linked to amyotrophic lateral sclerosis and frontotemporal dementia show up in stress granules. These natural RNA-protein accumulations protect essential RNAs in times of cellular strife, but cause trouble if they fail

Paper Alert: TDP-43 Mouse No Model to Test ALS Therapeutics

RESEARCH NEWS 2013-11-20 Research News In a paper in press in Brain Research, researchers have given one mouse model of TDP-43 proteinopathy a thumbs-down. While it was the first such mouse to be published (see Oct 2009 news story), it fails to mimic key features of amyotrophic l

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