PAPER Seijffers R, Mills CD, Woolf CJ
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PAPER Seijffers R, Allchorne AJ, Woolf CJ
The transcription factor ATF-3 promotes neurite outgrowth.
Mol Cell Neurosci. 2006 May-Jun;32(1-2):143-54. Epub 2006 May 19 PubMed: 16713293Raymond Bartus on Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
COMMENT The study by Palfi et al. is a welcome addition to the literature, reporting the results of 15 Parkinson’s patients treated with a lenti-viral vector intended to enhance dopamine function in the terminal field of the degenerating dopamine neurons. The tri
Raymond Bartus
RTBioconsultantsSan Diego, United States
Barbara Tate on GSAP Revisited: Does It Really Play a Role in Processing Aβ?
COMMENT The irreproducibility of the literature data also impacts the speed and cost of discovering new therapies. The commitment to start an industry drug-discovery program is an expensive proposition, and risky if based only on the scientific literature because
Laurel Beckett on Japanese ADNI Called to Defend Its Data Handling
COMMENT I know about the J-ADNI allegations mostly through our colleagues in Japan. My first impression, at a distance and through several filters, is that the allegations represent a misinterpretation of a standard data-checking process that, as such things do,
Takashi Asada on Japanese ADNI Called to Defend Its Data Handling
COMMENT I am pleased to have this opportunity to clear up this situation. First, allegations of falsification of data made by me are themselves false. I conducted a press conference on January 10, where I stated that large-scale data sets are susceptible to error
Japanese ADNI Called to Defend Its Data Handling
COMMUNITY NEWS 2014-01-17 Community News Allegations of falsified clinical data rocked the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) on January 10. An unidentified project researcher made the claims to the Japanese health ministry, which in turn questioned J-AD
Laurel Beckett
University of California, Davis, School of MedicineDavis
Jeffrey Jasper
CytokineticsSouth San Francisco, United States
Nicotinic Acetylcholine Receptors 2014
CONFERENCE 2014-07-23 00:00:00-2014-07-26 00:00:00 Churchill College, Cambridge, U.K. 23 July 2014 to 26 July 2014 This is the third Wellcome Trust conference on nicotinic acetylcholine receptors, following highly successful meetings in 2008 and 2011. nAChRs remain a focus of innovative research: from hig
Takashi Asada
University of Tsukuba
PAPER Haulcomb MM, Mesnard NA, Batka RJ, Alexander TD, Sanders VM, Jones KJ
Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice.
J Comp Neurol. 2014 Jul 1;522(10):2349-76. PubMed: 24424947PAPER Scotter EL, Vance C, Nishimura AL, Lee YB, Chen HJ, Urwin H, Sardone V, Mitchell JC, Rogelj B, Rubinsztein DC, Shaw CE
Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species.
J Cell Sci. 2014 Mar 15;127(Pt 6):1263-78. Epub 2014 Jan 14 PubMed: 24424030PAPER Tripathi VB, Baskaran P, Shaw CE, Guthrie S
Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo.
Neurobiol Dis. 2014 May;65:25-34. Epub 2014 Jan 11 PubMed: 24423647Current Filters
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