CONFERENCE COVERAGE 2016-10-28 Add Private note Add An editorial note Conference Coverage Potential side effects remain a major concern for BACE inhibitor programs. Knocking out the gene for BACE1 in mice causes a variety of troubling phenotypes, not least being brain seizures (see ...
PAPER Loos M, Mueller T, Gouwenberg Y, Wijnands R, van der Loo RJ, Neuro-BSIK Mouse Phenomics Consortium, Birchmeier C, Smit AB, Spijker S24703509
PAPER Hayes LN, Shevelkin A, Zeledon M, Steel G, Chen PL, Obie C, Pulver A, Avramopoulos D, Valle D, Sawa A, Pletnikov MV27606322
PAPER Pettem KL, Yokomaku D, Takahashi H, Ge Y, Craig AM23358245
PAPER Miyazaki T, Hashimoto K, Uda A, Sakagami H, Nakamura Y, Saito SY, Nishi M, Kume H, Tohgo A, Kaneko I, Kondo H, Fukunaga K, Kano M, Watanabe M, Takeshima H
Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family.FEBS Lett. 2006 Jul 24;580(17):4057-64. Epub 2006 Jun 27 PubMed: 16814779
RESEARCH NEWS 2016-10-28 Add Private note Add An editorial note Research News Genetic variants in the BIN1 gene increase risk for late-onset Alzheimer’s disease. Scientists want to know why, and a paper in the October 18 Cell Reports blames tau. Researchers led by Patrik ...
PAPER Pant S, Sharma M, Patel K, Caplan S, Carr CM, Grant BD19915558
Spring, United States
COMMENT These two papers present a comprehensive addition to our knowledge of the mechanisms of action of C9ORF72 dipeptide repeats. Studying other protein aggregates, investigators identified a plethora of protein interactions, which lead to the general ...
COMMENT These papers convincingly argue that toxicity due to C9ORF72 GGGGCC repeat expansions arises from arginine dipeptide repeats (DPRs) interactions with proteins containing low-complexity domain (LCDs) inside ribonucleoprotein granule membrane-less ...
PAPER Subudhi BB, Sahu PK
Angiotensin Mediated Oxidative Stress and Neuroprotective Potential of Antioxidants and AT1 Receptor Blockers.Mini Rev Med Chem. 2016 Oct 24; PubMed: 27781960
PAPER Malik R, Choudhary BS, Srivastava S, Mehta P, Sharma M
Identification of novel Acetylcholinesterase inhibitors through e-pharmacophore based virtual screening and molecular dynamics simulations.J Biomol Struct Dyn. 2016 Oct 26;:1-29. PubMed: 27782777
PAPER Ram S27780988
PAPER Pchelina S, Emelyanov A, Baydakova G, Andoskin P, Senkevich K, Nikolaev M, Miliukhina I, Yakimovskii A, Timofeeva A, Fedotova E, Abramycheva N, Usenko T, Kulabukhova D, Lavrinova A, Kopytova A, Garaeva L, Nuzhnyi E, Illarioshkin S, Zakharova E
Oligomeric α-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson's disease.Neurosci Lett. 2016 Oct 22; PubMed: 27780739
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