PSEN1 P117S

MUTATIONS PSEN1 73640284 GRCh37/hg19 rs63750550 C T g.25552C> T g.42106C> T Exon 5 Point, Missense Coding Increased Aβ42/40 ratio and decreased Aβ37/40, Aβ37/42, and Aβ38/42 ratios in transfected cells, indicating reduced γ-processivity. Increased production

PSEN1 P117A

MUTATIONS PSEN1 73640284 GRCh37/hg19 C G g.25552C> G g.42106C> G Exon 5 Point, Missense Coding Increased Aβ42/40 and Aβ42/Aβ total ratios and decreased Aβ37/40, Aβ37/42, and Aβ38/42 ratios.  Unknown. P117A Alzheimer's Disease: PathogenicAlzheimer's

Elvis Martis

Bombay College of Pharmacy. University of Mumbai
Mumbai, India

Limited Protein Shapes May Explain Drug Side Effects

RESEARCH NEWS 2013-05-28 Research News A new study explains why many drugs come with similar side effects—nausea, vomiting, headaches—bad enough to halt development in its tracks. Researchers from the Georgia Institute of Technology, Atlanta, predict that proteins form fewer than

Anna Magdalena Kedzierska

CINV
Valparaiso, Chile

Hilal Lashuel on Aβ Fibrils Drive Oligomer Formation, New Model Suggests

COMMENT Recent studies from a joint collaboration between our group and the Dietler laboratory at the EPFL provide, for the first time, direct evidence that Aβ42 fibrillization occurs via a combined mechanism of nucleated polymerization and secondary nucleation (

PAPER Carrieri A, Pérez-Nueno VI, Lentini G, Ritchie DW

Recent Trends and Future Prospects in Computational GPCR Drug Discovery: From Virtual Screening to Polypharmacology.

Curr Top Med Chem. 2013 May 1;13(9):1069-1097. PubMed: 23651484

PAPER Bolognesi ML

Polypharmacology in a single drug: multitarget drugs.

Curr Med Chem. 2013 Apr 1;20(13):1639-45. PubMed: 23410164

PAPER Kell DB

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

FEBS J. 2013 Mar 28; PubMed: 23552054

PAPER Skolnick J, Gao M

Interplay of physics and evolution in the likely origin of protein biochemical function.

Proc Natl Acad Sci U S A. 2013 May 20; PubMed: 23690621

PAPER Reddy AS, Zhang S

Polypharmacology: drug discovery for the future.

Expert Rev Clin Pharmacol. 2013 Jan;6(1):41-7. PubMed: 23272792

Michelle Pearson

West Point, United States

Silvia Cadena

Colombia

Brian Lawlor

Ireland

PAPER Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, van den Berg LH, Ringel S

Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14 Suppl 1:5-18. PubMed: 23678876