Michael Lardelli on Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins.
COMMENT The paper by Liao et al. suggests a revision of our understanding of the biological role of the amyloid precursor protein and its relationship to vasculature. The authors use gene trapping in zebrafish where GFP coding sequences become fused to the coding