PAPER Dewey FE, Chen R, Cordero SP, Ormond KE, Caleshu C, Karczewski KJ, Whirl-Carrillo M, Wheeler MT, Dudley JT, Byrnes JK, Cornejo OE, Knowles JW, Woon M, Sangkuhl K, Gong L, Thorn CF, Hebert JM, Capriotti E, David SP, Pavlovic A, West A, Thakuria JV, Ball MP, Zaranek AW, Rehm HL, Church GM, West JS, Bustamante CD, Snyder M, Altman RB, Klein TE, Butte AJ, Ashley EA

Phased whole-genome genetic risk in a family quartet using a major allele reference sequence.

PLoS Genet. 2011 Sep;7(9):e1002280. PubMed: 21935354

Paolo Sassone-Corsi on Genetic Testing a Foggy Crystal Ball at Best?

COMMENT The study by Vogelstein and colleagues constitutes a milestone for the field of human genetics, and has critical ramifications both medically and socially. By challenging the long-standing dogma that genetic testing would automatically provide absolute in

Svante Paabo on Genetic Testing a Foggy Crystal Ball at Best?

COMMENT In general, this paper is sobering. I would have naïvely thought that monozygotic twins would be more similar in the diseases that afflict them. Perhaps this may be seen as positive, in that our destiny is not in our genes. Rather, many other things that

PAPER Wray NR, Yang J, Goddard ME, Visscher PM

The genetic interpretation of area under the ROC curve in genomic profiling.

PLoS Genet. 2010 Feb;6(2):e1000864. PubMed: 20195508

PAPER Janssens AC, Aulchenko YS, Elefante S, Borsboom GJ, Steyerberg EW, van Duijn CM

Predictive testing for complex diseases using multiple genes: fact or fiction?

Genet Med. 2006 Jul;8(7):395-400. PubMed: 16845271

Paolo Sassone-Corsi

University of California, Irvine
Irvine, United States

Svante Paabo

Max-Planck Institute for Evolutionary Anthropology
Leizpig, Germany

Yu Zhang

VA Palo Alto Health Care
Palo Alto, United States

PAPER Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M

Personal omics profiling reveals dynamic molecular and medical phenotypes.

Cell. 2012 Mar 16;148(6):1293-307. PubMed: 22424236

Charles Glabe on Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS.

COMMENT This recent paper by Glass and coworkers reports further insight into the recognition of misfolded SOD1 by the conformation-dependent antibody C4F6. This antibody was originally isolated by Jean-Pierre Julien in 2007. This antibody was prepared by immuniz

Genetic Testing a Foggy Crystal Ball at Best?

RESEARCH NEWS 2012-04-04 Research News Sequencing a person’s entire genome will foretell many diseases only marginally better than gazing into a crystal ball, according to a report in the April 2 Science Translational Medicine online. Researchers at Johns Hopkins University in Ba

Bapineuzumab Crops CSF Tau Levels

RESEARCH NEWS 2012-04-04 Research News The concentration of tau in the cerebrospinal fluid drops with bapineuzumab treatment, according to a post-hoc analysis of Phase 2 clinical trial results published online April 2 in the Archives of Neurology. After one year of treatment with

Keystone: Does ApoE Fragmentation Drive Pathology?

CONFERENCE COVERAGE 2012-04-04 Conference Coverage Fragmentation can bog down your hard drive, and some scientists think it also wreaks havoc on processing in the brain. At “ApoE, Alzheimer’s and Lipoprotein Biology,” a Keystone symposium held 26 February-2 March 2012 in Keystone, Colo

PAPER Kalkonde YV, Jawaid A, Qureshi SU, Shirani P, Wheaton M, Pinto-Patarroyo GP, Schulz PE

Medical and environmental risk factors associated with frontotemporal dementia: a case-control study in a veteran population.

Alzheimers Dement. 2012 May;8(3):204-10. PubMed: 22465176

PAPER Kruse N, Schulz-Schaeffer WJ, Schlossmacher MG, Mollenhauer B

Development of electrochemiluminescence-based singleplex and multiplex assays for the quantification of α-synuclein and other proteins in cerebrospinal fluid.

Methods. 2012 Apr;56(4):514-8. PubMed: 22465793