GRANT Friday, November 28, 2014- 14:00 Alzheimer's Research UK £500,000 23 January 2015 Global Clinical Trials Fund ...
Martin Citron on Pharmacological Inhibition of Beta Site Amyloid Precursor Protein Cleaving Enzyme 1 Can Impair Synaptic Plasticity and Sepcific Cognitive Functions
COMMENT Over the last years a number of studies have addressed potential on-target liabilities of therapeutic BACE1 inhibition. Many of these studies were based on knockout data alone, or addressed developmental myelination. In contrast, the new study by Herms ...
Stefan Lichtenthaler on Pharmacological Inhibition of Beta Site Amyloid Precursor Protein Cleaving Enzyme 1 Can Impair Synaptic Plasticity and Sepcific Cognitive Functions
COMMENT This is an interesting paper, which fits well with earlier findings reported from Phil Wong’s lab in BACE1-deficient mice (Savonenko et al., 2008). After Carmen Birchmeier’s report last year (Cheret et al., 2013), this is now another story demonstrating ...
RESEARCH NEWS 2014-11-28 Research News The goal of BACE1 inhibition is to stop the production of toxic Aβ. However, a new study reports that at very high doses, the inhibitors may harm the very neurons they are meant to protect. Initial findings were presented by senior author ...
PAPER Taymans JM, Baekelandt V
Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism.Front Genet. 2014;5:382. Epub 2014 Nov 7 PubMed: 25426138
PAPER Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JA
Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease.Front Cell Neurosci. 2014;8:369. Epub 2014 Nov 11 PubMed: 25426023
PAPER Grey M, Dunning CJ, Gaspar R, Grey C, Brundin P, Sparr E, Linse S25425650
PAPER Wan WB, Cao L, Liu LM, Kalionis B, Chen C, Tai XT, Li YM, Xia SJ
EGb761 Provides a Protective Effect against Aβ1-42 Oligomer-Induced Cell Damage and Blood-Brain Barrier Disruption in an In Vitro bEnd.3 Endothelial Model.PLoS One. 2014;9(11):e113126. Epub 2014 Nov 26 PubMed: 25426944
PAPER Walsh KP, Kuhn TB, Bamburg JR
Cellular prion protein: a co-receptor mediating neuronal cofilin-actin rod formation induced by β-amyloid and proinflammatory cytokines.Prion. 2014 Sep 9; PubMed: 25426519
PAPER Lee JM, Shin MS, Ji ES, Kim TW, Cho HS, Kim CJ, Jang MS, Kim TW, Kim BK, Kim DH
Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer's disease rats.J Exerc Rehabil. 2014 Oct;10(5):258-264. Epub 2014 Oct 31 PubMed: 25426461
PAPER Farhad SZ, Amini S, Khalilian A, Barekatain M, Mafi M, Barekatain M, Rafei E
The effect of chronic periodontitis on serum levels of tumor necrosis factor-alpha in Alzheimer disease.Dent Res J (Isfahan). 2014 Sep;11(5):549-552. PubMed: 25426144
PAPER Darusman HS, Gjedde A, Sajuthi D, Schapiro SJ, Kalliokoski O, Kristianingrum YP, Handaryani E, Hau J
Amyloid Beta1-42 and the Phoshorylated Tau Threonine 231 in Brains of Aged Cynomolgus Monkeys (Macaca fascicularis).Front Aging Neurosci. 2014;6:313. Epub 2014 Nov 10 PubMed: 25426069
PAPER Wilkins HM, Carl SM, Greenlief AC, Festoff BW, Swerdlow RH25426068
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