Can a Fly Screen Trap Alzheimer’s Gene Candidates?

RESEARCH NEWS 2011-02-11 Research News Large genomewide association studies keep hatching new genetic variants associated with Alzheimer’s disease. To capitalize on this information, scientists need a way to quickly swat false positives and narrow in on the specific genes that tr

PAPER Eslinger PJ, Moore P, Anderson C, Grossman M

Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia.

J Neuropsychiatry Clin Neurosci. 2011 Fall;23(1):74-82. PubMed: 21304142

PAPER Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, Sargent IL, Wood MJ, Cooper JM

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

Neurobiol Dis. 2011 Jun;42(3):360-7. PubMed: 21303699

PAPER Davies P, Moualla D, Brown DR

Correction: alpha-synuclein is a cellular ferrireductase.

PLoS One. 2011;6(1) PubMed: 21304915

PAPER Matrisciano F, Busceti CL, Bucci D, Orlando R, Caruso A, Molinaro G, Cappuccio I, Riozzi B, Gradini R, Motolese M, Caraci F, Copani A, Scaccianoce S, Melchiorri D, Bruno V, Battaglia G, Nicoletti F

Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

PLoS One. 2011;6(1):e16447. PubMed: 21304589

PAPER Matsuoka Y

Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder?

Biopsychosoc Med. 2011;5:3. PubMed: 21303552

PAPER Sasaki Y, Milbrandt J

Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

J Biol Chem. 2010 Dec 31;285(53):41211-5. PubMed: 21071441

PAPER Tokuda K, O'Dell KA, Izumi Y, Zorumski CF

Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis.

J Neurosci. 2010 Dec 15;30(50):16788-95. PubMed: 21159950

PAPER Mattsson N

CSF biomarkers in neurodegenerative diseases.

Clin Chem Lab Med. 2011 Mar;49(3):345-52. PubMed: 21303297

PAPER Chang YC, Hung WT, Chang HC, Wu CL, Chiang AS, Jackson GR, Sang TK

Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.

PLoS Genet. 2011;7(2):e1001288. PubMed: 21304887

PAPER Thomas B, Mandir AS, West N, Liu Y, Andrabi SA, Stirling W, Dawson VL, Dawson TM, Lee MK

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.

PLoS One. 2011;6(1):e16706. PubMed: 21304957

PAPER Schmidt MV, Trümbach D, Weber P, Wagner K, Scharf SH, Liebl C, Datson N, Namendorf C, Gerlach T, Kühne C, Uhr M, Deussing JM, Wurst W, Binder EB, Holsboer F, Müller MB

Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus.

J Neurosci. 2010 Dec 15;30(50):16949-58. PubMed: 21159965

PAPER Casula M, Iyer AM, Spliet WG, Anink JJ, Steentjes K, Sta M, Troost D, Aronica E

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue.

Neuroscience. 2011 Apr 14;179:233-43. PubMed: 21303685

PAPER Harada C, Guo X, Namekata K, Kimura A, Nakamura K, Tanaka K, Parada LF, Harada T

Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration.

Nat Commun. 2011;2:189. PubMed: 21304518

PAPER Nunes A, Pressey SN, Cooper JD, Soriano S

Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.

Neurobiol Dis. 2011 Jun;42(3):349-59. PubMed: 21303697