Mark Cookson on LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.
COMMENT This study by Lin et al. provides an excellent opportunity to reevaluate the proposed role of LRRK2 on neurite outgrowth and maintenance. Work from the Abeliovich lab first showed that LRRK2, and especially mutant LRRK2, can limit the outgrowth of neurite