PAPER Liu YJ, Fu Y
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PAPER Chung YG, Eum JH, Lee JE, Shim SH, Sepilian V, Hong SW, Lee Y, Treff NR, Choi YH, Kimbrel EA, Dittman RE, Lanza R, Lee DR
Human somatic cell nuclear transfer using adult cells.
Cell Stem Cell. 2014 Jun 5;14(6):777-80. Epub 2014 Apr 17 PubMed: 24746675Roslyn Stanford
Calwell, Australia
Does Dendritic Tau Promote Plasticity?
RESEARCH NEWS 2014-04-25 Research News In Alzheimer’s brains, the axonal protein tau strays into dendritic spines and stirs up trouble at synapses. Researchers have called this a mislocalization, but a paper in the April 23 Journal of Neuroscience challenges this view, suggesting
Hans Zempel on Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.
COMMENT This study from the Buisson lab adds more data arguing that tau may contribute to the regulation of synaptic plasticity. It has long been known that tau can bind to f-actin, particularly when phosphorylated at the KXGS-motifs (Mandelkow et al., 2004; Whit
C9ORF72 Repeats Expand into New Disorders—Cause, or Coincidence?
RESEARCH NEWS 2014-04-25 Research News Long repeat sequences in the C9ORF72 gene have cropped up in cases of multiple system atrophy (MSA) and depressive pseudodementia, according to two new case studies. The findings, published in JAMA Neurology on April 14 and 21, respectively,
Barbara Elmer
Germany
PAPER MacArthur DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J, Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, Daly MJ, Gerstein MB, Goldstein DB, Hirschhorn JN, Leal SM, Pennacchio LA, Stamatoyannopoulos JA, Sunyaev SR, Valle D, Voight BF, Winckler W, Gunter C
Guidelines for investigating causality of sequence variants in human disease.
Nature. 2014 Apr 24;508(7497):469-76. PubMed: 24759409Jürgen Götz on Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.
COMMENT I enjoyed reading this paper. The study adds to the notion that a prime function of tau is that of a scaffolding protein, not only in the axon but also in the dendrite where tau interacts, as this study shows, also with filamentous actin. Interesting is t
Matthew Wynn
University of California San FranciscoSan Francisco, United States
Erik Roberson on Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.
COMMENT This is a very interesting and elegant study that adds support for the idea that tau is normally present in dendrites and plays a physiological role in normal synaptic functioning. The movement of tau into spines with neuronal activity is demonstrated in
PAPER Frandemiche ML, De Seranno S, Rush T, Borel E, Elie A, Arnal I, Lanté F, Buisson A
Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.
J Neurosci. 2014 Apr 23;34(17):6084-97. PubMed: 24760868PAPER
NIH focuses on the brain.
J Nucl Med. 2013 Dec;54(12):9N. PubMed: 24297742PAPER Mohammadi D
INMiND: getting to the bottom of neuroinflammation.
Lancet Neurol. 2013 Dec;12(12):1135-6. PubMed: 24229613PAPER Sharma M, Krüger R, Gasser T
From genome-wide association studies to next-generation sequencing: lessons from the past and planning for the future.
JAMA Neurol. 2014 Jan;71(1):5-6. PubMed: 24190229Current Filters
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