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Does Dendritic Tau Promote Plasticity?

RESEARCH NEWS 2014-04-25 Research News In Alzheimer’s brains, the axonal protein tau strays into dendritic spines and stirs up trouble at synapses. Researchers have called this a mislocalization, but a paper in the April 23 Journal of Neuroscience challenges this view, suggesting

C9ORF72 Repeats Expand into New Disorders—Cause, or Coincidence?

RESEARCH NEWS 2014-04-25 Research News Long repeat sequences in the C9ORF72 gene have cropped up in cases of multiple system atrophy (MSA) and depressive pseudodementia, according to two new case studies. The findings, published in JAMA Neurology on April 14 and 21, respectively,

PAPER MacArthur DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J, Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, Daly MJ, Gerstein MB, Goldstein DB, Hirschhorn JN, Leal SM, Pennacchio LA, Stamatoyannopoulos JA, Sunyaev SR, Valle D, Voight BF, Winckler W, Gunter C

Guidelines for investigating causality of sequence variants in human disease.

Nature. 2014 Apr 24;508(7497):469-76. PubMed: 24759409

Matthew Wynn


University of California San Francisco
San Francisco, United States

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