PAPER Lestaevel P, Bensoussan H, Racine R, Airault F, Gourmelon P, Souidi M
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PAPER Vannini P, Hedden T, Becker JA, Sullivan C, Putcha D, Rentz D, Johnson KA, Sperling RA
Age and amyloid-related alterations in default network habituation to stimulus repetition.
Neurobiol Aging. 2011 Feb 17; PubMed: 21334099PAPER Zhang RY, Leon AC, Chuang-Stein C, Romano SJ
A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease.
Clin Trials. 2011 Feb;8(1):5-14. PubMed: 21335586PAPER Shafaati M, Marutle A, Pettersson H, Lövgren-Sandblom A, Olin M, Pikuleva I, Winblad B, Nordberg A, Björkhem I
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.
J Lipid Res. 2011 May;52(5):1004-10. PubMed: 21335619PAPER Yochim BP, Mueller AE, Kane KD, Kahook MY
Prevalence of Cognitive Impairment, Depression, and Anxiety Symptoms Among Older Adults With Glaucoma.
J Glaucoma. 2011 Feb 17; PubMed: 21336151Elaine Bearer on Herpes Simplex and Alzheimer’s—Time to Think Again?
COMMENT Our work has focused on intracellular/axonal transport. In the process of investigating the signatures on cargo that recruit microtubule-based transport machinery, we used herpes simplex virus and discovered an interaction between HSV particles and cellul
Wai-Tong Chien on Stress and AD—The Cognition Connection
COMMENT It is very important and interesting to read Wilson and his colleagues' research on whether stress or proneness to distress is a risk factor for, or a sign of, cognitive decline. They acknowledged that the latter is possible, but favor the idea that
PAPER Caracciolo B, Bäckman L, Monastero R, Winblad B, Fratiglioni L
The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population.
J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):788-93. PubMed: 21212108Lawrence Friedhoff on Herpes Simplex and Alzheimer’s—Time to Think Again?
COMMENT I have been skeptical that abnormal β amyloid or tau were the primary cause of Alzheimer's disease for some time. As a person who led the development of the main drug used to treat the cognitive symptoms of the disease, it was my experience that disc
Chris Carter on Herpes Simplex and Alzheimer’s—Time to Think Again?
COMMENT Perhaps one of the important pieces of evidence is the high enrichment of herpes simplex binding proteins in plaques and tangles in the Alzheimer's disease brain, with p values rivaling those found in GWAS! (See Carter, 2010.) These structures also c
Melvyn Ball on Herpes Simplex and Alzheimer’s—Time to Think Again?
COMMENT Further to my Limbic-Predilection "Hypothesis" paper (Ball, 1982) suggesting HSV1 as a cause of AD, the key question that cell biologists must now answer is why neurofibrillary tangles always appear first in the aging and the demented person
Takaomi Saido on Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.
COMMENT Whole-genome sequencing should be the one. 0 saido
Takaomi Saido on Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy.
COMMENT This is a very important study. 0 saido
Takaomi Saido on Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles.
COMMENT Interesting. 0 saido
Torik Ayoubi
KU LeuvenLeuven, Belgium
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