PAPER Devanand DP, Pelton GH, Cunqueiro K, Sackeim HA, Marder K

A 6-month, randomized, double-blind, placebo-controlled pilot discontinuation trial following response to haloperidol treatment of psychosis and agitation in Alzheimer's disease.

Int J Geriatr Psychiatry. 2011 Sep;26(9):937-43. PubMed: 21845596

PAPER Guo X, Wu X, Ren L, Liu G, Li L

Epigenetic mechanisms of amyloid-β production in anisomycin-treated SH-SY5Y cells.

Neuroscience. 2011 Oct 27;194:272-81. PubMed: 21843603

PAPER Xiong F, Leonov S, Howard AC, Xiong S, Zhang B, Mei L, McNeil P, Simon S, Xiong WC

Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a beta-catenin-dependent manner.

J Biol Chem. 2011 Oct 7;286(40):35061-70. PubMed: 21844192

Lawrence Rajendran on ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.

COMMENT This elegant cell biology study adds another important piece to the puzzle of how endocytosis controls amyloid production. A few years ago, we showed that APP and BACE are internalized into early endosomes where β cleavage occurs (Rajendran et al., 2006).

Jed Johnson

Nanofiber Solutions
Columbus, United States

Gopika Nigam

Dr Babasaheb Ambedkar Marathwada University
AURANGABAD, India

PAPER Davey MJ, Sayers TJ, Baum H

Letter: Autoantigenicity of subcellular membranes.

Lancet. 1975 Jan 25;1(7900):228-9. PubMed: 47467

PAPER Rohrer JD

Structural brain imaging in frontotemporal dementia.

Biochim Biophys Acta. 2011 Jul 30; PubMed: 21839829

PAPER Burrell JR, Kiernan MC, Vucic S, Hodges JR

Motor neuron dysfunction in frontotemporal dementia.

Brain. 2011 Sep;134(Pt 9):2582-94. PubMed: 21840887

PAPER Hughes LE, Nestor PJ, Hodges JR, Rowe JB

Magnetoencephalography of frontotemporal dementia: spatiotemporally localized changes during semantic decisions.

Brain. 2011 Sep;134(Pt 9):2513-22. PubMed: 21840892

PAPER Kim HT, So JH, Jung SH, Ahn DG, Koh W, Kim NS, Kim SH, Lee S, Kim CH

Cug2 is essential for normal mitotic control and CNS development in zebrafish.

BMC Dev Biol. 2011;11:49. PubMed: 21838932

PAPER Al-Saif A, Al-Mohanna F, Bohlega S

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis.

Ann Neurol. 2011 Dec;70(6):913-9. PubMed: 21842496

PAPER Schneider A, Mehmood T, Pannetier S, Hanauer A

Altered ERK/MAPK signaling in the hippocampus of the mrsk2_KO mouse model of Coffin-Lowry syndrome.

J Neurochem. 2011 Nov;119(3):447-59. PubMed: 21838783

PAPER Sari Y

Huntington's Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy.

Int J Biomed Sci. 2011 Jun;7(2):89-100. PubMed: 21841917

PAPER Qiu C, Cheng S, Xia Y, Peng B, Tang Q, Tu B

Effects of subchronic benzo(a)pyrene exposure on neurotransmitter receptor gene expression in the rat hippocampus related with spatial learning and memory change.

Toxicology. 2011 Nov 18;289(2-3):83-90. PubMed: 21839799