COMMENT First, these data essentially confirm the common ABCA7 GWAS SNP as a legitimate genetic risk for Alzheimer's disease. Overall, this story is a nice integration of the rare variant/robust risk and common variant/modest risk thought process. SNPs with ...
PAPER Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.Atherosclerosis. 2011 Aug;217(2):407-14. Epub 2011 Jun 23 PubMed: 21762915
COMMENT Steinberg and colleagues provide new compelling evidence for the genetic association between loss-of-function variants in the lipid transporter ABCA7 and increased risk of Alzheimer’s disease. Whole-genome sequences of 2,636 Icelanders were imputed into ...
PAPER Chinetti-Gbaguidi G, Baron M, Bouhlel MA, Vanhoutte J, Copin C, Sebti Y, Derudas B, Mayi T, Bories G, Tailleux A, Haulon S, Zawadzki C, Jude B, Staels B
Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.Circ Res. 2011 Apr 15;108(8):985-95. Epub 2011 Feb 24 PubMed: 21350215
PAPER Dalli J, Serhan CN
Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators.Blood. 2012 Oct 11;120(15):e60-72. Epub 2012 Aug 17 PubMed: 22904297
PAPER Quazi F, Molday RS
Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants.J Biol Chem. 2013 Nov 29;288(48):34414-26. Epub 2013 Oct 4 PubMed: 24097981
COMMENT Loss-of-function variants in ABCA7 highlight an important role in Alzheimer’s disease Early in vitro studies suggested that ABCA7 may play a protective role in Alzheimer’s disease (AD) (Chan et al., 2008). Interest in the association of ABCA7 with AD has ...
PAPER Kim WS, Guillemin GJ, Glaros EN, Lim CK, Garner B
Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells.Neuroreport. 2006 Jun 26;17(9):891-6. PubMed: 16738483
PAPER Kaminski WE, Orsó E, Diederich W, Klucken J, Drobnik W, Schmitz G10873640
RESEARCH NEWS 2015-03-26 Research News The March 25 Nature Genetics details the largest set of human genomes ever sequenced. Senior author Kari Stefansson and colleagues from deCODE genetics, a subsidiary of Amgen based in Reykjavik, Iceland, sequenced whole genomes of more than ...
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PAPER Iwamoto N, Abe-Dohmae S, Sato R, Yokoyama S
ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis.J Lipid Res. 2006 Sep;47(9):1915-27. Epub 2006 Jun 20 PubMed: 16788211
PAPER Wu YC, Horvitz HR9635425
PAPER Abe-Dohmae S, Ikeda Y, Matsuo M, Hayashi M, Okuhira K, Ueda K, Yokoyama S
Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.J Biol Chem. 2004 Jan 2;279(1):604-11. Epub 2003 Oct 21 PubMed: 14570867
PAPER Helgason A, Einarsson AW, Guðmundsdóttir VB, Sigurðsson Á, Gunnarsdóttir ED, Jagadeesan A, Ebenesersdóttir SS, Kong A, Stefánsson K25807285
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