PAPER Neltner JH, Abner EL, Schmitt FA, Denison SK, Anderson S, Patel E, Nelson PT
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PAPER Winer L, Srinivasan D, Chun S, Lacomis D, Jaffa M, Fagan A, Holtzman DM, Wancewicz E, Bennett CF, Bowser R, Cudkowicz M, Miller TM
SOD1 in Cerebral Spinal Fluid as a Pharmacodynamic Marker for Antisense Oligonucleotide Therapy.
Arch Neurol. 2012 Nov 12;:1-7. PubMed: 23147550PAPER
Alzheimer disease: Hormone therapy and the risk of AD-timing may be key.
Science. 2013 Jan 18;339(6117):321-4. PubMed: 23147847PAPER
Alzheimer disease: Cladribine promotes amyloid plaque formation in mice.
Science. 2013 Jan 18;339(6117):321-4. PubMed: 23147852Michael Heneka on Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk
COMMENT Triggering receptor expressed on myeloid cells 2 (TREM2) represents a surface receptor without its own intracellular signaling motif. It therefore depends on the adaptor protein 12 (DAP12) for the initiation of signaling cascades. TREM2 has been primarily
PAPER Bouchon A, Dietrich J, Colonna M
Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.
J Immunol. 2000 May 15;164(10):4991-5. PubMed: 10799849PAPER Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL
Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.
J Immunol. 2006 Aug 15;177(4):2051-5. PubMed: 16887962PAPER Takahashi K, Rochford CD, Neumann H
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.
J Exp Med. 2005 Feb 21;201(4):647-57. PubMed: 15728241PAPER Sessa G, Podini P, Mariani M, Meroni A, Spreafico R, Sinigaglia F, Colonna M, Panina P, Meldolesi J
Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia.
Eur J Neurosci. 2004 Nov;20(10):2617-28. PubMed: 15548205Bruno Pietro Imbimbo on CTAD: New Data on Sola, Bapi, Spark Theragnostics Debate
COMMENT Soluble β amyloid has a beneficial physiological role for the normal functioning of neurons. In the AD brain, the increase in soluble β amyloid concentrations, mainly via a decrease in its clearance, could simply represent the brain's attempt to medi
Bruno Pietro Imbimbo
Chiesi Farmaceutici S.p.A.Parma, Italy
Ann Smith
School of Biological Sciences, University of Missouri-Kansas CityKansas City, United States
Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk
RESEARCH NEWS 2012-11-14 Research News Rare mutations in a microglial receptor contribute as much to Alzheimer’s risk as does the more common ApoE4 genotype, according to back-to-back papers in the November 14 New England Journal of Medicine online. Variants in the triggering rec
CTAD: ApoE Carriers Sought for Trial of NSAID Derivative
CONFERENCE COVERAGE 2012-11-14 Conference Coverage Updated 29 November 2012 The 5th Clinical Trials in Alzheimer’s Disease conference, held 29-31 October in Monaco, featured a new Phase 2 program that uses genetics to enrich an MCI population for an early-stage therapeutic trial. The d
PAPER Peyer AK, Kinter J, Hench J, Frank S, Fuhr P, Thomann S, Fischmann A, Kneifel S, Camaño P, Munain AL, Sinnreich M, Renaud S
Novel valosin containing protein mutation in a Swiss family with hereditary inclusion body myopathy and dementia.
Neuromuscul Disord. 2013 Feb;23(2):149-54. PubMed: 23140793Current Filters
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