PAPER Reijmer YD, Leemans A, Caeyenberghs K, Heringa SM, Koek HL, Biessels GJ,
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PAPER Jicha GA, Rentz DM
Cognitive and brain reserve and the diagnosis and treatment of preclinical Alzheimer disease.
Neurology. 2013 Mar 26;80(13):1180-1. PubMed: 23486882Sylvain Lesne on Correlation of Specific Amyloid-β Oligomers With Tau in Cerebrospinal Fluid From Cognitively Normal Older Adults.
COMMENT The measurements of CSF oligomeric Aβ were done by immunoprecipitation/Western blot using as little as 240 μL per determination (ran as triplicate, then averaged). Using such a low volume suggests it may be possible to integrate similar measurements in lo
Guy Lippens on An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
COMMENT The authors describe the generation of novel avian antibodies against several phospho-epitopes of tau. Notably, they go far in the molecular characterization of an antibody recognizing the pThr231-Pro epitope. This antibody recognizes the tangles in AD-de
David Brody on Correlation of Specific Amyloid-β Oligomers With Tau in Cerebrospinal Fluid From Cognitively Normal Older Adults.
COMMENT The topic is important, and the results are intriguing. The issue of Aβ oligomerization is a complex one, and several methodological questions could be raised: 1. The immunoprecipitation with 6E10 and Western blotting with 6E10 may not distinguish between
Prakriti Sehgal on Nicastrin—A DAPper Role in γ-Secretase
COMMENT Excellent, and a very useful study by Yu et al. The article has proved to be quite informative to me, and I am sure will assist me in my research work. Thank you for this commendable work. nature.ps8 0