Vincent Yannella
APA affiliationMilford, United States
330026 RESULTS
APA affiliationMilford, United States
COMMENT The elegant paper by Takeda et al. demonstrates that crossing APP-overexpressing mice with leptin-deficient mice, a model of a metabolic syndrome including hyperglycemia, exacerbates the cognitive decline observed in APP mice (APP23). The effect was obser
PAPER Didion SP, Lynch CM, Baumbach GL, Faraci FM
PAPER Kennedy AJ, Ellacott KL, King VL, Hasty AH
COMMENT This paper by Fuhrmann et al. shows elegant two-photon imaging of neurons and microglia in the 3x transgenic model. It is certainly a technical tour de force. The most striking result is that there is neuron loss in this model, which has not been previous
COMMENT My 2006 publication (excerpt below) explicitly described Aβ as an antimicrobial peptide based on its multiple similarities to melittin. In addition, the described antimicrobial action was explicitly cited as a basis for Aβ to be considered a component of
PITTSBURGH, United States
RESEARCH NEWS 2010-03-29 Research News The production of toxic Aβ peptides from amyloid precursor protein (APP) proceeds via the sequential cleavage of the extracellular domain by β-secretase, followed by an intramembrane cut by γ-secretase. However, if α-secretase finds APP firs
France Alzheimer HeraultFrance
ANTIBODY polyclonal manufacturer cat# 18584 immunogen = human Amyloid β liquid, supernatant, affinity purified reactivity to Amyloid β (1-40), (1-42), and (1-43) IgG Amyloid-β DEMEDITEC Diagnostics GmbH Rabbit Human Amyloid beta (NT) http://alzforum.org/res/com/an
ANTIBODY monoclonal 14F1 manufacturer cat# 11110 immunogen = synthetic human Amyloid β (1-16) liquid, supernatant, affinity purified recognizes A-β; 26% cross reactivity to full length APP IgG<sub>1</sub> Amyloid-β DEMEDITEC Diagnostics GmbH Mouse Huma
ANTIBODY monoclonal 12B2 manufacturer cat# 10027 immunogen = human Amyloid β liquid, supernatant, affinity purified recognizes A-β(1-40), A-β (1-42), A-β (1-43) IgG<sub>1</sub> Amyloid-β DEMEDITEC Diagnostics GmbH Mouse Human Amyloid beta (11-28) http:
ANTIBODY kit manufacturer cat# JP27729 immunogen = human Amyloid β recognizes A-β(1-40), A-β (1-42), A-β (1-28); no cross reactivity to A-β (1-16), (-3-40), (-1-40), (2-40), (3-40) Amyloid-β DEMEDITEC Diagnostics GmbH Unknown Host Amyloid beta http://alzforum.org/
ANTIBODY polyclonal manufacturer Cat# 55359<br />Anti-p38 MAPK-a/b (CT), Z-Fish™ immunogen = a synthetic peptide corresponding to the carboxyl terminus (CT) of zebrafish p38 MAPK-a and MAPK-b. liquid, affinity purified, PBS, azide detects p38 MAPK IH recomme
ANTIBODY polyclonal manufacturer Cat# 54419 immunogen = a synthetic peptide corresponding to the N-terminus of human p38. liquid, affinity purified, PBS, azide detects p38 MAPK IP recommended, not tested p38 MAPK & MAPK11-14 Anaspec Rabbit Bovine Dog Human Mon
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