David Gillam on Focus on the Locus! (Ceruleus, That Is, in Alzheimer’s Disease)
COMMENT Any new drugs that affect amyloid in the brain? davidgillam 0
331161 RESULTS
COMMENT Any new drugs that affect amyloid in the brain? davidgillam 0
COMMENT Two prominent messages emerge from the Sephton paper and the burgeoning literature on TDP-43: 1) TDP-43 is important for the normal functioning of cells; and 2) its actions are many and complex. This being so, is it realistic to assume that targeting one
COMMENT I think the locus ceruleus is definitely implicated in Alzheimer’s disease, perhaps in some way mediating synaptic plasticity, which is an early casualty in the Alzheimer’s disease war on the brain. I had treated a number of mice and rats in the early 198
COMMENT The dog models do probably have a lot of advantages over mice, especially since they seem to be endogenous models rather than induced through genetic manipulation. Another large animal model that seems to be largely overlooked is equine motor neuron disea
PAPER Divers TJ, Cummings JE, de Lahunta A, Hintz HF, Mohammed HO
PAPER Han F, Shioda N, Moriguchi S, Yamamoto Y, Raie AY, Yamaguchi Y, Hino M, Fukunaga K
PAPER Shioda N, Yamamoto Y, Han F, Moriguchi S, Yamaguchi Y, Hino M, Fukunaga K