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ORM-12741

THERAPEUTICS Orion Pharma Small Molecule Other Neurotransmitters From 2008 to 2010, Orion Pharma had conducted seven Phase 1 trials for ORM-12741 in a total of more than 200 healthy volunteers in Finland, France, and the Netherlands. These studies evaluated absorption

Minocycline

THERAPEUTICS Solodyn Arestin Minocin Dynacin Small Molecule Other In May, 2014, a Phase 2, multicenter trial began enrolling people with mild AD from National Health Service memory clinics in Scotland and England. Participation required a clinical diagnosis and a stan

SAR110894D

THERAPEUTICS Sanofi Small Molecule Other Alzheimer's Disease Phase 2 Breaking News

Rilapladib

THERAPEUTICS GlaxoSmithKline (GSK) SB-659032 Small Molecule Other In October 2011, GSK started enrolling 124 people with mild to moderate Alzheimer's disease into a Phase 2 study comparing 250 mg of rilapladib taken once daily to placebo. This study primarily eva

Nasal Insulin

THERAPEUTICS Detemir Levemir Humulin Novolin glulisine Small Molecule Other Amyloid-Related Other A single-center pilot study at the Veterans Affairs Hospital/University of Washington in Seattle reported improved verbal memory retention and attention after a three-wee

MSDC-0160

THERAPEUTICS Metabolic Solutions Development Company Mitoglitazone Small Molecule Other Alzheimer's Disease Phase 2 Breaking News

Circadin

THERAPEUTICS Neurim Pharmaceuticals Ltd. Small Molecule Other One trial of Circadin 2 mg, as add-on to standard therapy, has been conducted in Alzheimer's disease patients. Starting in 2009 at five sites in the United States and the United Kingdom, 73 male and fe

EVP-0962

THERAPEUTICS FORUM Pharmaceuticals Inc. EVP 0015962 Small Molecule Amyloid-Related In 2011, FORUM Pharmaceuticals Inc. (formerly called EnVivo Pharmaceuticals), ran an ascending single- and multiple-dose Phase 1 study to assess safety, tolerability, pharmacology, and

Nelonicline

THERAPEUTICS AbbVie ABT-126 Small Molecule Cholinergic System ABT-126 was in Phase 2 development for Alzheimer's disease in the United States, Canada, South Africa, and Eastern European countries, and in Phase 3 development for cognitive symptoms in schizophrenia

CHF 5074

THERAPEUTICS CereSpir™ Incorporated Chiesi Pharmaceuticals Inc. Small Molecule Amyloid-Related Inflammation Other Phase 1 clinical trials consisted of three studies in 144 healthy young men to establish pharmacology and initial safety data. CH 5074 was reported to be

Epigallocatechin Gallate (EGCG)

THERAPEUTICS Taiyo International Sunphenon EGCg Supplement, Dietary Amyloid-Related Inflammation Other More than 60 trials on various EGCG extracts and formulations have been conducted or are ongoing, the majority on various types of cancer.  In Alzheimer's disea

Avagacestat

THERAPEUTICS Bristol-Myers Squibb BMS-708163 Small Molecule Amyloid-Related About a dozen Phase 1 trials evaluated avagacestat's safety and pharmacology in healthy volunteers and people with Alzheimer's disease. In particular, drug interaction studies were c

Bexarotene

THERAPEUTICS Ligand Pharmaceuticals, Inc. ReXceptor Inc. Targretin® Small Molecule Amyloid-Related Unknown In 2014, a Phase 2 biomarker proof-of-concept study at the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas evaluated the effect of a one-month bli

Continuous Positive Airway Pressure

THERAPEUTICS CPAP Procedural Intervention Unknown In the early 2000s, a controlled, randomized trial at the University of California, San Diego, tested a three- and a six-week course of CPAP in 52 people with mild to moderate Alzheimer’s and obstructive sleep apnea. T

Dexpramipexole

THERAPEUTICS (R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole Biogen Knopp Biosciences LLC Virginia Commonwealth University R-pramipexole RPPX KNS-760704 BIIB 050 Small Molecule Other Neurotransmitters Other Biogen Idec conducted four Phase 1 studies to ass

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