PAPER Roberts GW, Gentleman SM, Lynch A, Graham DI
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PAPER Rudelli R, Strom JO, Welch PT, Ambler MW
Posttraumatic premature Alzheimer's disease. Neuropathologic findings and pathogenetic considerations.
Arch Neurol. 1982 Sep;39(9):570-5. PubMed: 7115146PAPER Mathis CA, Kuller LH, Klunk WE, Snitz BE, Price JC, Weissfeld LA, Rosario BL, Lopresti BJ, Saxton JA, Aizenstein HJ, McDade EM, Kamboh MI, DeKosky ST, Lopez OL
In vivo assessment of amyloid-β deposition in nondemented very elderly subjects.
Ann Neurol. 2013 Jun;73(6):751-61. Epub 2013 Apr 17 PubMed: 23596051Sam Gandy on Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study.
COMMENT I think that there a lot of uncontrolled and unknowable variables at work here. The post traumatic brain injury (TBI) amyloidosis probably peaks very early and then might be resolved completely. I assume that the propensities for depositing and the speed
Does a Blow to the Head Mean More Amyloid Down the Road?
RESEARCH NEWS 2014-01-10 Research News Scientists disagree about the long-term consequences of head injury and whether it leads to Alzheimer's disease later in life (see AlzRisk entry). It may vary from person to person, suggests a report in the January 7 Neurology. Scientis
PAPER Wang HK, Lin SH, Sung PS, Wu MH, Hung KW, Wang LC, Huang CY, Lu K, Chen HJ, Tsai KJ
Population based study on patients with traumatic brain injury suggests increased risk of dementia.
J Neurol Neurosurg Psychiatry. 2012 Nov;83(11):1080-5. Epub 2012 Jul 27 PubMed: 22842203Familial ALS More Common Than Thought—Do We Need a New Definition?
RESEARCH NEWS 2014-01-10 Research News Amyotrophic lateral sclerosis runs in families more often than scientists originally thought. Researchers have claimed that 5 percent of ALS cases are inherited, with the remainder being sporadic, but a paper in the January 7 Neurology raise
PAPER Andersen PM, Al-Chalabi A
Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
Nat Rev Neurol. 2011 Oct 11;7(11):603-15. PubMed: 21989245PAPER Al-Chalabi A, Fang F, Hanby MF, Leigh PN, Shaw CE, Ye W, Rijsdijk F
An estimate of amyotrophic lateral sclerosis heritability using twin data.
J Neurol Neurosurg Psychiatry. 2010 Dec;81(12):1324-6. Epub 2010 Sep 22 PubMed: 20861059PAPER Byrne S, Bede P, Elamin M, Kenna K, Lynch C, McLaughlin R, Hardiman O
Proposed criteria for familial amyotrophic lateral sclerosis.
Amyotroph Lateral Scler. 2011 May;12(3):157-9. Epub 2011 Jan 5 PubMed: 21208036PAPER Hanby MF, Scott KM, Scotton W, Wijesekera L, Mole T, Ellis CE, Leigh PN, Shaw CE, Al-Chalabi A
The risk to relatives of patients with sporadic amyotrophic lateral sclerosis.
Brain. 2011 Dec;134(Pt 12):3454-7. Epub 2011 Sep 20 PubMed: 21933809PAPER Fang F, Kamel F, Lichtenstein P, Bellocco R, Sparén P, Sandler DP, Ye W
Familial aggregation of amyotrophic lateral sclerosis.
Ann Neurol. 2009 Jul;66(1):94-9. PubMed: 19670447PAPER Johnston CA, Stanton BR, Turner MR, Gray R, Blunt AH, Butt D, Ampong MA, Shaw CE, Leigh PN, Al-Chalabi A
Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London.
J Neurol. 2006 Dec;253(12):1642-3. PubMed: 17219036PAPER Byrne S, Walsh C, Lynch C, Bede P, Elamin M, Kenna K, McLaughlin R, Hardiman O
Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis.
J Neurol Neurosurg Psychiatry. 2011 Jun;82(6):623-7. Epub 2010 Nov 3 PubMed: 21047878Raphael Kopan on GSAP Revisited: Does It Really Play a Role in Processing Aβ?
COMMENT I did not try to reproduce He et al. 2010 myself but agree with the shortcomings of this data as reported in this story. If patient data suggest there will be no efficacy, I question whether it is worth resolving the remaining data discrepancies at this p
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