Aβ Oligomers Linked to ER Stress in Patient-Derived Neurons

RESEARCH NEWS 2013-02-22 Research News Research published in the February 21 Cell Stem Cell solidifies the case that human neurons made from reprogrammed patient cells can help scientists unravel pathological mechanisms behind Alzheimer's disease and evaluate potential thera

PAPER Pasquier F, Deramecourt V, Lebert F

[From Pick's disease to frontotemporal dementia].

Bull Acad Natl Med. 2012 Feb;196(2):431-42; discussion 442-3. PubMed: 23420961

PAPER Snowden JS, Harris J, Richardson A, Rollinson S, Thompson JC, Neary D, Mann DM, Pickering-Brown S

Frontotemporal dementia with amyotrophic lateral sclerosis: a clinical comparison of patients with and without repeat expansions in C9orf72.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14(3):172-6. PubMed: 23421625

PAPER Houseman G, Walsh S, Brothers A, Lyter J, Simmons Z, Klapper J

Frontotemporal degeneration in the patient with amyotrophic lateral sclerosis: helping the caregiver cope.

J Neurosci Nurs. 2013 Apr;45(2):96-100. PubMed: 23422695

PAPER Reddy K, Zamiri B, Stanley SY, Macgregor RB, Pearson CE

The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures.

J Biol Chem. 2013 Apr 5;288(14):9860-6. PubMed: 23423380

PAPER Liachko NF, McMillan PJ, Guthrie CR, Bird TD, Leverenz JB, Kraemer BC

CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.

Ann Neurol. 2013 Feb 19; PubMed: 23424178

PAPER Estrada-Sánchez AM, Rebec GV

Role of cerebral cortex in the neuropathology of Huntington's disease.

Front Neural Circuits. 2013;7:19. PubMed: 23423362

PAPER Yang Z, Huh SU, Drennan JM, Kathuria H, Martinez JS, Tsuda H, Hall MC, Clemens JC

Drosophila Vap-33 is required for axonal localization of Dscam isoforms.

J Neurosci. 2012 Nov 28;32(48):17241-50. PubMed: 23197716

PAPER Ayton S, Lei P, Duce JA, Wong BX, Sedjahtera A, Adlard PA, Bush AI, Finkelstein DI

Ceruloplasmin dysfunction and therapeutic potential for parkinson disease.

Ann Neurol. 2012 Nov 24; PubMed: 23424051

PAPER Morales-García JA, Susín C, Alonso-Gil S, Pérez DI, Palomo V, Pérez C, Conde S, Santos A, Gil C, Martínez A, Pérez-Castillo A

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.

ACS Chem Neurosci. 2013 Feb 20;4(2):350-60. PubMed: 23421686

PAPER Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N

Voxel-Wise Co-analysis of Macro- and Microstructural Brain Alteration in Mild Cognitive Impairment and Alzheimer's Disease Using Anatomical and Diffusion MRI.

J Neuroimaging. 2013 Feb 19; PubMed: 23421601

PAPER Limapichat W, Yu WY, Branigan E, Lester HA, Dougherty DA

Key Binding Interactions for Memantine in the NMDA Receptor.

ACS Chem Neurosci. 2013 Feb 20;4(2):255-60. PubMed: 23421676

PAPER Coskuner O, Wise-Scira O, Perry G, Kitahara T

The structures of the E22Δ mutant-type amyloid-β alloforms and the impact of E22Δ mutation on the structures of the wild-type amyloid-β alloforms.

ACS Chem Neurosci. 2013 Feb 20;4(2):310-20. PubMed: 23421682

PAPER More SS, Vartak AP, Vince R

Restoration of glyoxalase enzyme activity precludes cognitive dysfunction in a mouse model of Alzheimer's disease.

ACS Chem Neurosci. 2013 Feb 20;4(2):330-8. PubMed: 23421684

PAPER Veloso AJ, Dhar D, Chow AM, Zhang B, Tang DW, Ganesh HV, Mikhaylichenko S, Brown IR, Kerman K

sym-Triazines for directed multitarget modulation of cholinesterases and amyloid-β in Alzheimer's disease.

ACS Chem Neurosci. 2013 Feb 20;4(2):339-49. PubMed: 23421685