Lars Nilsson on Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.

COMMENT The important early observation that PDAPP mice hemizygous for murine ApoE (PDAPP x mouse ApoE+/-) had less Aβ and amyloid burden than those with two copies (PDAPP x mouse ApoE+/+) (Bales et al., 1997; Bales et al., 1999) is unfortunately seldom mentioned

Michael Heneka on Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons.

COMMENT This is a highly interesting paper that sheds further light on the fate of the noradrenergic system during the course of Alzheimer's disease. Central noradrenergic neurons, located in the locus ceruleus (LC), degenerate early in AD, and subsequently,

Stephen Strittmatter

Yale University School of Medicine
United States

Wai-Tong Chien on Parkinson’s: Thinking Outside the Brain’s Black Box

COMMENT This is a useful and important paper on the experimental findings to support Braak's hypothesis, which has provided new ideas for researchers to test the role of functional tracts and brain structure in Alzheimer's disease, including Lewy bodies

PAPER Takeda A, Baba T, Kikuchi A, Sugeno N, Hasegawa T, Itoyama Y, Ishioka T, Hirayama K, Mori E

[Pathophysiological process underlying Parkinson's disease: motor & non-motor symptoms].

Rinsho Shinkeigaku. 2009 Nov;49(11):888-9. PubMed: 20030239

Haakon Nygaard

Yale University School of Medicine
United States

Lane Simonian on Proinflammatory cytokines, sickness behavior, and Alzheimer disease.

COMMENT As Holmes and his colleagues have discovered, tumor necrosis factor-α plays a key role in Alzheimer's disease—although that role may be more due to its induction of peroxynitrites than to inflammation (Hikiji et al., 2000). Peroxynitrite damage is wi

PAPER Hikiji H, Shin WS, Koizumi T, Takato T, Susami T, Koizumi Y, Okai-Matsuo Y, Toyo-Oka T

Peroxynitrite production by TNF-alpha and IL-1beta: implication for suppression of osteoblastic differentiation.

Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1031-7. PubMed: 10827005

Chris Carter on 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study.

COMMENT This is more a question than a comment. Both PIB and β amyloid antibodies bind to the same relatively small peptide, β amyloid. Is there any work testing whether they displace each other? 0 chris_car

Ivan Martynikhin

St.Petersburg Pavlov State Medical University
St. Petersburg, Russian Federation

PAPER Borroni B, Pilotto A, Bianchi M, Gilberti N, Padovani A

Genetic contributors to frontotemporal lobar degeneration: beyond monogenic disease.

Mini Rev Med Chem. 2011 Oct 1;11(11):988-1001. PubMed: 21762097

PAPER Shannon KM, Keshavarzian A, Mutlu E, Dodiya HB, Daian D, Jaglin JA, Kordower JH

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.

Mov Disord. 2011 Jul 15; PubMed: 21766334

PAPER Xu X, Li T, Luo Q, Hong X, Xie L, Tian D

Bisphenol-A rapidly enhanced passive avoidance memory and phosphorylation of NMDA receptor subunits in hippocampus of young rats.

Toxicol Appl Pharmacol. 2011 Sep 1;255(2):221-8. PubMed: 21763338

PAPER Vilariño-Güell C, Wider C, Ross OA, Dachsel JC, Kachergus JM, Lincoln SJ, Soto-Ortolaza AI, Cobb SA, Wilhoite GJ, Bacon JA, Behrouz B, Melrose HL, Hentati E, Puschmann A, Evans DM, Conibear E, Wasserman WW, Aasly JO, Burkhard PR, Djaldetti R, Ghika J, Hentati F, Krygowska-Wajs A, Lynch T, Melamed E, Rajput A, Rajput AH, Solida A, Wu RM, Uitti RJ, Wszolek ZK, Vingerhoets F, Farrer MJ

VPS35 Mutations in Parkinson Disease.

Am J Hum Genet. 2011 Jul 15;89(1):162-7. PubMed: 21763482

PAPER Lelan F, Boyer C, Thinard R, Rémy S, Usal C, Tesson L, Anegon I, Neveu I, Damier P, Naveilhan P, Lescaudron L

Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease.

Parkinsons Dis. 2011;2011:987084. PubMed: 21766003