PAPER Trazzi S, Fuchs C, Valli E, Perini G, Bartesaghi R, Ciani E

The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome.

J Biol Chem. 2013 Jul 19;288(29):20817-29. PubMed: 23740250

PAPER Silva DF, Selfridge JE, Lu J, E L, Roy N, Hutfles L, Burns JM, Michaelis EK, Yan S, Cardoso SM, Swerdlow RH

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines.

Hum Mol Genet. 2013 Jun 13; PubMed: 23740939

PAPER Fukui T, Oowan Y, Yamazaki T, Kinno R

Prevalence and clinical implication of microbleeds in dementia with lewy bodies in comparison with microbleeds in Alzheimer's disease.

Dement Geriatr Cogn Dis Extra. 2013 Jan;3(1):148-60. PubMed: 23741227

PAPER Torjesen I

Study links drugs for Alzheimer's disease with reduced risk of heart attack and death.

BMJ. 2013;346:f3669. PubMed: 23741033

PAPER Shibata N, Motoi Y, Tomiyama H, Ohnuma T, Kuerban B, Tomson K, Komatsu M, Shimazaki H, Hattori N, Arai H

Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer's Disease and Parkinson's Disease with Dementia.

Dement Geriatr Cogn Dis Extra. 2013 Jan;3(1):161-7. PubMed: 23741228

PAPER Shah RC, Janos AL, Kline JE, Yu L, Leurgans SE, Wilson RS, Wei P, Bennett DA, Heilman KM, Tsao JW

Cognitive decline in older persons initiating anticholinergic medications.

PLoS One. 2013;8(5):e64111. PubMed: 23741303

PAPER Koehler NK, Stransky E, Shing M, Gaertner S, Meyer M, Schreitmüller B, Leyhe T, Laske C, Maetzler W, Kahle P, Celej MS, Jovin TM, Fallgatter AJ, Batra A, Buchkremer G, Schott K, Richartz-Salzburger E

Altered Serum IgG Levels to α-Synuclein in Dementia with Lewy Bodies and Alzheimer's Disease.

PLoS One. 2013;8(5):e64649. PubMed: 23741358

PAPER Dyrba M, Ewers M, Wegrzyn M, Kilimann I, Plant C, Oswald A, Meindl T, Pievani M, Bokde AL, Fellgiebel A, Filippi M, Hampel H, Klöppel S, Hauenstein K, Kirste T, Teipel SJ,

Robust automated detection of microstructural white matter degeneration in Alzheimer's disease using machine learning classification of multicenter DTI data.

PLoS One. 2013;8(5):e64925. PubMed: 23741425

PAPER Antes R, Ezra-Elia R, Weinberger D, Solomon A, Ofri R, Michaelson DM

ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice.

PLoS One. 2013;8(5):e64949. PubMed: 23741431

PAPER Bosomworth HJ, Adlard PA, Ford D, Valentine RA

Altered expression of ZnT10 in Alzheimer's disease brain.

PLoS One. 2013;8(5):e65475. PubMed: 23741496

PAPER Lambracht-Washington D, Rosenberg RN

Active DNA Aβ42 vaccination as immunotherapy for Alzheimer disease.

Transl Neurosci. 2012 Dec 1;3(4):307-313. PubMed: 23741624

Orly Lazarov on Newborn Neurons Abundant in Adult Human Hippocampus

COMMENT These observations clearly determine that the extent of hippocampal neurogenesis is comparable in humans and rodents, and provide profound evidence for the critical role of neurogenesis in the human dentate gyrus. Several noteworthy unknowns in this study

PSEN1 L424H

MUTATIONS PSEN1 73685864 GRCh37/hg19 rs63751032 T A g.71075T> A g.87686T> A Exon 12 Point, Missense Coding Increased Aβ42/Aβ40 and Aβ43; decreased Aβ37/Aβ42. Unknown; generalized cerebral atrophy by MRI; diffuse cerebral hypoperfusion by SPECT. L424H Alzheime

PSEN1 L424F

MUTATIONS PSEN1 73685863 GRCh37/hg19 C T g.71074C> T g.87685C> T Exon 12 Point, Missense Coding Increased Aβ42/Aβ40 and decreased Aβ37/Aβ42 in cultured cells.     Unknown, but neuroimaging in two patients revealed brain atrophy with white-matter changes. L424

PSEN1 L424V

MUTATIONS PSEN1 73685863 GRCh37/hg19 C G g.71074C> G g.87685C> G Exon 12 Point, Missense Coding Increased Aβ40, Aβ42, and Aβ42/Aβ40 in vitro. Unknown; CT and SPECT imaging showed diffuse cortical and subcortical atrophy and hypoperfusion affecting the frontal