Takaomi Saido on The off-rate of monomers dissociating from amyloid-β protofibrils.

COMMENT This is a very important study. What would the kinetics be if the authors used amyloid protofibrils and filbrils isolated from human brains? 0 saido

Jürgen Götz on Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β.

COMMENT A very elegant study done in mice, rats, and monkeys showing that clearance of Aβ from the brain is most likely not because of a sink effect between this organ and the periphery. 0 j.goetz

Jürgen Götz on Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model.

COMMENT This is an interesting paper that supports our findings in mouse models and cell lines that soluble tau is toxic, as evidenced by the trapping of the kinesin adapter protein JIP1 in the soma under conditions where tau levels (irrespective of a pathogenic

MAPT A227A

MUTATIONS MAPT 44073889 GRCh37/hg19 rs1052553 A G g.109929A> G g.107103A> G Exon 9 Point, Silent Coding Unknown. This variant segregates with the H2 haplotype, which may be associated with decreased tau levels in the brain. Not applicable. A227A Frontotempora

PAPER Gordon RY, Kapralova MV, Godukhin OV, Arkhipov VI

Memory Disorders in Rats after Impairment of the Dorsal Hippocampal CA3 Field with Kainic Acid.

Bull Exp Biol Med. 2013 Sep;155(6):805-8090. PubMed: 24288771

PAPER Molino I, Colucci L, Fasanaro AM, Traini E, Amenta F

Efficacy of memantine, donepezil, or their association in moderate-severe Alzheimer's disease: a review of clinical trials.

ScientificWorldJournal. 2013;2013:925702. Epub 2013 Oct 29 PubMed: 24288512

Kimberly S Leight

Huntington's patient
Raleigh, United States

David Holtzman on Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.

COMMENT This paper beautifully shows that by using a unique method of AAV-mediated gene delivery via the choroid plexus and ependyma, relatively small increases in expression of human ApoE4 are achieved that increase Aβ deposition and toxicity, while ApoE2 has th

Angeliki Nikolakopoulou on Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.

COMMENT In this interesting study, the authors demonstrate that the ApoE4 gene variant increases amyloid plaque load, promotes synaptic loss and neuritic dystrophy in close proximity to the plaques, and delays Aβ clearance. In contrast, ApoE2 expression decreases

Cheryl Wellington on Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.

COMMENT Although the association of ApoE with AD risk and age of onset is indisputable, whether ApoE is a tractable therapeutic target remains an open question. Brad Hyman’s group has recently published a paper that adds considerable strength to the therapeutic p

Henrietta Nielsen on Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.

COMMENT In this elegantly performed study, Hudry and colleagues addressed a few important gaps in the literature on ApoE and its links to amyloid pathology and Alzheimer’s disease. By using a still-unexplored strategy of adding the three different human ApoE isof

PAPER El-Azab MF, Baldowski BR, Mysona BA, Shanab AY, Mohamed IN, Abdelsaid MA, Matragoon S, Bollinger KE, Saul A, El-Remessy AB

Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.

Br J Pharmacol. 2014 Mar;171(5):1299-313. PubMed: 24283717

PAPER Vantaggiato C, Clementi E, Bassi MT

ZFYVE26/SPASTIZIN: a close link between complicated hereditary spastic paraparesis and autophagy.

Autophagy. 2014 Feb;10(2):374-5. Epub 2013 Nov 26 PubMed: 24284334

PAPER Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke.

Stroke. 2012 Jul;43(7):1918-24. PubMed: 22535263

PAPER Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

J Neurosci. 2013 Nov 27;33(48):18712-27. PubMed: 24285878