SEARCH RESULTS

329938 RESULTS

Ashkan Javaherian on Yeast Chaperone Melts Protein Aggregates

COMMENT The new findings by Jackrel and Shorter are an important and exciting extension of their previous work published earlier this year. They had previously engineered a variant of Hsp104 to reverse aggregation of misfolded proteins associated with Parkinson&#

Aaron Gitler on Yeast Chaperone Melts Protein Aggregates

COMMENT This manuscript by Jackrel and Shorter is an extension of the tour de force Cell paper published by these authors earlier this year (Jackrel et al., 2014). In that manuscript, they engineered the protein disaggregase Hsp104,which normally has no activity

Yeast Chaperone Melts Protein Aggregates

RESEARCH NEWS 2014-08-08 Research News Rejiggered chaperones untangle aggregates and refold mutant proteins associated with amyotrophic lateral sclerosis, frontotemporal dementia, and Parkinson’s disease, according to a paper in the July 25 Disease Models & Mechanisms online.

PAPER Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee VM, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

Hum Mol Genet. 2012 Jul 1;21(13):2899-911. Epub 2012 Mar 27 PubMed: 22454397

Searching for Evidence of Neurodegeneration in the Blood

RESEARCH NEWS 2014-08-08 Research News Given the invasiveness and expense of measuring brain biomarkers for neurodegenerative diseases, researchers are searching for alternatives. Despite little success thus far, they continue to comb the complex jumble of proteins and molecules

PAPER Stefansson H, Helgason A, Thorleifsson G, Steinthorsdottir V, Masson G, Barnard J, Baker A, Jonasdottir A, Ingason A, Gudnadottir VG, Desnica N, Hicks A, Gylfason A, Gudbjartsson DF, Jonsdottir GM, Sainz J, Agnarsson K, Birgisdottir B, Ghosh S, Olafsdottir A, Cazier JB, Kristjansson K, Frigge ML, Thorgeirsson TE, Gulcher JR, Kong A, Stefansson K

A common inversion under selection in Europeans.

Nat Genet. 2005 Feb;37(2):129-37. Epub 2005 Jan 16 PubMed: 15654335

Current Filters

No filters selected

Filter By

DATE RANGE
  • All
  • Past 7 Days
  • Past 30 Days
  • Past 90 Days
  • Past 12 Months
  • Specific Dates
    1. From
      To

TYPE