PAPER Dowling JK, O'Neill LA
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PAPER Canevelli M, Talarico G, Tosto G, Troili F, Lenzi GL, Bruno G
Rivastigmine in the Treatment of Hypersexuality in Alzheimer Disease.
Alzheimer Dis Assoc Disord. 2012 Jun 6; PubMed: 22683665PAPER Schrijvers EM, Verhaaren BF, Koudstaal PJ, Hofman A, Ikram MA, Breteler MM
Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study.
Neurology. 2012 May 8;78(19):1456-63. PubMed: 22551732Joel Buxbaum on Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.
COMMENT Some of the authors' observations are not surprising, from our view, since they performed an in-vitro incubation of Aβ oligomers with transthyretin (TTR), and we (and others) have shown that such an incubation will inhibit Aβ fibril formation, oligom
Kevin Roth on Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.
COMMENT A variety of caspases have been implicated over the last 15 years in regulating the extensive neuron degeneration that occurs in Alzheimer's disease. Originally, most investigators focused on the effector caspase, caspase-3, whose activity in many ex
PAPER Stanger K, Steffek M, Zhou L, Pozniak CD, Quan C, Franke Y, Tom J, Tam C, Elliott JM, Lewcock JW, Zhang Y, Murray J, Hannoush RN
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.
Nat Chem Biol. 2012 Jul;8(7):655-60. PubMed: 22683611Jae-Sung Lim
�Korea, Republic of
Clamp Keeps Caspase-6 From Driving Cell to Its Death
RESEARCH NEWS 2012-06-12 Research News Taking the road less traveled may prove beneficial when it comes to certain therapeutic targets. In the June 10 Nature Chemical Biology, researchers published a new way to tackle a cell death enzyme that causes neurodegeneration and may lead
Raul Delgado-Morales
Bellvitge Biomedical Research Institute (IDIBELL)Barcelona, Spain
Olesya Rezanova
Minsk, Belarus
New Web Forum Set to Tackle Multiple Sclerosis
COMMUNITY NEWS 2012-06-11 Community News Alzforum welcomes a new member to the fold. The Multiple Sclerosis Discovery Forum (MSDF) provides, for free, a wealth of information for researchers studying multiple sclerosis (MS) and related disorders. Like Alzforum and similar forums f
PAPER Héron B, Valayannopoulos V, Baruteau J, Chabrol B, Ogier H, Latour P, Dobbelaere D, Eyer D, Labarthe F, Maurey H, Cuisset JM, de Villemeur TB, Sedel F, Vanier MT
Miglustat therapy in the French cohort of paediatric patients with Niemann-Pick disease type C.
Orphanet J Rare Dis. 2012;7:36. PubMed: 22676771PAPER Chao PK, Lu KT, Jhu JY, Wo YY, Huang TC, Ro LS, Yang YL
Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression.
J Neuroinflammation. 2012;9:121. PubMed: 22676811PAPER Gu J, Shi J, Wu S, Jin N, Qian W, Zhou J, Iqbal IG, Iqbal K, Gong CX, Liu F
Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10.
FEBS Lett. 2012 Jul 30;586(16):2239-44. PubMed: 22677170PAPER Maltecca F, De Stefani D, Cassina L, Consolato F, Wasilewski M, Scorrano L, Rizzuto R, Casari G
Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation.
Hum Mol Genet. 2012 Sep 1;21(17):3858-70. PubMed: 22678058Current Filters
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