PAPER Bergh J, Zetterström P, Andersen PM, Brännström T, Graffmo KS, Jonsson PA, Lang L, Danielsson J, Oliveberg M, Marklund SL25802384
RESEARCH NEWS 2015-03-27 Research News In February, scientists reported that TANK-binding kinase 1 was a potential amyotrophic lateral sclerosis gene. Now, another research group has arrived at the same conclusion, and even extended the association to frontotemporal dementia. As ...
PAPER Gunnarsson LG, Dahlbom K, Strandman E1776392
University of Delhi, New DelhiNew Delhi, India
PAPER Gallegos S, Pacheco C, Peters C, Opazo CM, Aguayo LG
Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease.Front Neurosci. 2015;9:59. Epub 2015 Mar 9 PubMed: 25805964
PAPER Mikhail F, Calingasan N, Parolari L, Subramanian A, Yang L, Beal MF
Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.Hum Mol Genet. 2015 Mar 24; PubMed: 25804954
COMMENT First, these data essentially confirm the common ABCA7 GWAS SNP as a legitimate genetic risk for Alzheimer's disease. Overall, this story is a nice integration of the rare variant/robust risk and common variant/modest risk thought process. SNPs with ...
PAPER Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.Atherosclerosis. 2011 Aug;217(2):407-14. Epub 2011 Jun 23 PubMed: 21762915
COMMENT Steinberg and colleagues provide new compelling evidence for the genetic association between loss-of-function variants in the lipid transporter ABCA7 and increased risk of Alzheimer’s disease. Whole-genome sequences of 2,636 Icelanders were imputed into ...
PAPER Chinetti-Gbaguidi G, Baron M, Bouhlel MA, Vanhoutte J, Copin C, Sebti Y, Derudas B, Mayi T, Bories G, Tailleux A, Haulon S, Zawadzki C, Jude B, Staels B
Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.Circ Res. 2011 Apr 15;108(8):985-95. Epub 2011 Feb 24 PubMed: 21350215
PAPER Dalli J, Serhan CN
Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators.Blood. 2012 Oct 11;120(15):e60-72. Epub 2012 Aug 17 PubMed: 22904297
PAPER Quazi F, Molday RS
Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants.J Biol Chem. 2013 Nov 29;288(48):34414-26. Epub 2013 Oct 4 PubMed: 24097981
COMMENT Loss-of-function variants in ABCA7 highlight an important role in Alzheimer’s disease Early in vitro studies suggested that ABCA7 may play a protective role in Alzheimer’s disease (AD) (Chan et al., 2008). Interest in the association of ABCA7 with AD has ...
PAPER Kim WS, Guillemin GJ, Glaros EN, Lim CK, Garner B
Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells.Neuroreport. 2006 Jun 26;17(9):891-6. PubMed: 16738483
PAPER Kaminski WE, Orsó E, Diederich W, Klucken J, Drobnik W, Schmitz G10873640
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